Macrosialin (Gp110) (CD antigen CD68)
1_MRLAV 6_ LFSGA 11_ LLGLL 16_ AAQGT 21_ GNDCP 26_ HKKSA 31_ TLLPS 36_ FTVTP 41_ TVTES 46_ TGTTS 51_ HRTTK 56_ SHKTT 61_ THRTT 66_ TTGTT 71_ SHGPT 76_ TATHN 81_ PTTTS 86_ HGNVT 91_ VHPTS 96_ NSTAT 101_ SQGPS 106_ TATHS 111_ PATTS 116_ HGNAT 121_ VHPTS 126_ NSTAT 131_ SPGFT 136_ SSAHP 141_ EPPPP 146_ SPSPS 151_ PTSKE 156_ TIGDY 161_ TWTNG 166_ SQPCV 171_ HLQAQ 176_ IQIRV 181_ MYTTQ 186_ GGGEA 191_ WGISV 196_ LNPNK 201_ TKVQG 206_ SCEGA 211_ HPHLL 216_ LSFPY 221_ GHLSF 226_ GFMQD 231_ LQQKV 236_ VYLSY 241_ MAVEY 246_ NVSFP 251_ HAAQW 256_ TFSAQ 261_ NASLR 266_ DLQAP 271_ LGQSF 276_ SCSNS 281_ SIILS 286_ PAVHL 291_ DLLSL 296_ RLQAA 301_ QLPHT 306_ GVFGQ 311_ SFSCP 316_ SDRSI 321_ LLPLI 326_ IGLIL 331_ LGLLA 336_ LVLIA 341_ FCIIR 346_RRPSA
1: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells