Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
1_MLYFS 6_ LFWAA 11_ RPLQR 16_ CGQLV 21_ RMAIR 26_ AQHSN 31_ AAQTQ 36_ TGEAN 41_ RGWTG 46_ QESLS 51_ DSDPE 56_ MWELL 61_ QREKD 66_ RQCRG 71_ LELIA 76_ SENFC 81_ SRAAL 86_ EALGS 91_ CLNNK 96_ YSEGY 101_ PGKRY 106_ YGGAE 111_ VVDEI 116_ ELLCQ 121_ RRALE 126_ AFDLD 131_ PAQWG 136_ VNVQP 141_ YSGSP 146_ ANLAV 151_ YTALL 156_ QPHDR 161_ IMGLD 166_ LPDGG 171_ HLTHG 176_ YMSDV 181_ KRISA 186_ TSIFF 191_ ESMPY 196_ KLNPK 201_ TGLID 206_ YNQLA 211_ LTARL 216_ FRPRL 221_ IIAGT 226_ SAYAR 231_ LIDYA 236_ RMREV 241_ CDEVK 246_ AHLLA 251_ DMAHI 256_ SGLVA 261_ AKVIP 266_ SPFKH 271_ ADIVT 276_ TTTHK 281_ TLRGA 286_ RSGLI 291_ FYRKG 296_ VKAVD 301_ PKTGR 306_ EIPYT 311_ FEDRI 316_ NFAVF 321_ PSLQG 326_ GPHNH 331_ AIAAV 336_ AVALK 341_ QACTP 346_ MFREY 351_ SLQVL 356_ KNARA 361_ MADAL 366_ LERGY 371_ SLVSG 376_ GTDNH 381_ LVLVD 386_ LRPKG 391_ LDGAR 396_ AERVL 401_ ELVSI 406_ TANKN 411_ TCPGD 416_ RSAIT 421_ PGGLR 426_ LGAPA 431_ LTSRQ 436_ FREDD 441_ FRRVV 446_ DFIDE 451_ GVNIG 456_ LEVKS 461_ KTAKL 466_ QDFKS 471_ FLLKD 476_ SETSQ 481_ RLANL 486_ RQRVE 491_ QFARA 496_FPMPG
1: Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985)