Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3)
1_MIITQ 6_ TSHCY 11_ MTSLG 16_ ILFLI 21_ NILPG 26_ TTGQG 31_ ESRRQ 36_ EPGDF 41_ VKQDI 46_ GGLSP 51_ KHAPD 56_ IPDDS 61_ TDNIT 66_ IFTRI 71_ LDRLL 76_ DGYDN 81_ RLRPG 86_ LGDAV 91_ TEVKT 96_ DIYVT 101_ SFGPV 106_ SDTDM 111_ EYTID 116_ VFFRQ 121_ TWHDE 126_ RLKFD 131_ GPMKI 136_ LPLNN 141_ LLASK 146_ IWTPD 151_ TFFHN 156_ GKKSV 161_ AHNMT 166_ TPNKL 171_ LRLVD 176_ NGTLL 181_ YTMRL 186_ TIHAE 191_ CPMHL 196_ EDFPM 201_ DVHAC 206_ PLKFG 211_ SYAYT 216_ TAEVV 221_ YSWTL 226_ GKNKS 231_ VEVAQ 236_ DGSRL 241_ NQYDL 246_ LGHVV 251_ GTEII 256_ RSSTG 261_ EYVVM 266_ TTHFH 271_ LKRKI 276_ GYFVI 281_ QTYLP 286_ CIMTV 291_ ILSQV 296_ SFWLN 301_ RESVP 306_ ARTVF 311_ GVTTV 316_ LTMTT 321_ LSISA 326_ RNSLP 331_ KVAYA 336_ TAMDW 341_ FIAVC 346_ YAFVF 351_ SALIE 356_ FATVN 361_ YFTKR 366_ SWAWE 371_ GKKVP 376_ EALEM 381_ KKKTP 386_ AAPAK 391_ KTSTT 396_ FNIVG 401_ TTYPI 406_ NLAKD 411_ TEFST 416_ ISKGA 421_ APSAS 426_ STPTI 431_ IASPK 436_ ATYVQ 441_ DSPTE 446_ TKTYN 451_ SVSKV 456_ DKISR 461_ IIFPV 466_ LFAIF 471_ NLVYW 476_ ATYVN 481_ RESAI 486_KGMIR
1: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:16412217, PubMed:29053855). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:16412217, PubMed:29053855)