Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]
1_MTLRA 6_ AVFDL 11_ DGVLA 16_ LPAVF 21_ GVLGR 26_ TEEAL 31_ ALPRG 36_ LLNDA 41_ FQKGG 46_ PEGAT 51_ TRLMK 56_ GEITL 61_ SQWIP 66_ LMEEN 71_ CRKCS 76_ ETAKV 81_ CLPKN 86_ FSIKE 91_ IFDKA 96_ ISARK 101_ INRPM 106_ LQAAL 111_ MLRKK 116_ GFTTA 121_ ILTNT 126_ WLDDR 131_ AERDG 136_ LAQLM 141_ CELKM 146_ HFDFL 151_ IESCQ 156_ VGMVK 161_ PEPQI 166_ YKFLL 171_ DTLKA 176_ SPSEV 181_ VFLDD 186_ IGANL 191_ KPARD 196_ LGMVT 201_ ILVQD 206_ TDTAL 211_ KELEK 216_ VTGIQ 221_ LLNTP 226_ APLPT 231_ SCNPS 236_ DMSHG 241_ YVTVK 246_ PRVRL 251_ HFVEL 256_ GSGPA 261_ VCLCH 266_ GFPES 271_ WYSWR 276_ YQIPA 281_ LAQAG 286_ YRVLA 291_ MDMKG 296_ YGESS 301_ APPEI 306_ EEYCM 311_ EVLCK 316_ EMVTF 321_ LDKLG 326_ LSQAV 331_ FIGHD 336_ WGGML 341_ VWYMA 346_ LFYPE 351_ RVRAV 356_ ASLNT 361_ PFIPA 366_ NPNMS 371_ PLESI 376_ KANPV 381_ FDYQL 386_ YFQEP 391_ GVAEA 396_ ELEQN 401_ LSRTF 406_ KSLFR 411_ ASDES 416_ VLSMH 421_ KVCEA 426_ GGLFV 431_ NSPEE 436_ PSLSR 441_ MVTEE 446_ EIQFY 451_ VQQFK 456_ KSGFR 461_ GPLNW 466_ YRNME 471_ RNWKW 476_ ACKSL 481_ GRKIL 486_ IPALM 491_ VTAEK 496_ DFVLV 501_ PQMSQ 506_ HMEDW 511_ IPHLK 516_ RGHIE 521_ DCGHW 526_ TQMDK 531_ PTEVN 536_ QILIK 541_ WLDSD 546_ARNPP
1: Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12574510, PubMed:12869654, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12574510, PubMed:12869654, PubMed:21217101, PubMed:22798687)
2: Bifunctional enzyme (PubMed:12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545)