Tyrosine-protein kinase RYK (EC 2.7.10.1)
1_MRGAA 6_ RLGRP 11_ GRSCL 16_ PGARG 21_ LRAPP 26_ PPPLL 31_ LLLAL 36_ LPLLP 41_ APGAA 46_ AAPAP 51_ RPPEL 56_ QSASA 61_ GPSVS 66_ LYLSE 71_ DEVRR 76_ LIGLD 81_ AELYY 86_ VRNDL 91_ ISHYA 96_ LSFSL 101_ LVPSE 106_ TNFLH 111_ FTWHA 116_ KSKVE 121_ YKLGF 126_ QVDNV 131_ LAMDM 136_ PQVNI 141_ SVQGE 146_ VPRTL 151_ SVFRV 156_ ELSCT 161_ GKVDS 166_ EVMIL 171_ MQLNL 176_ TVNSS 181_ KNFTV 186_ LNFKR 191_ RKMCY 196_ KKLEE 201_ VKTSA 206_ LDKNT 211_ SRTIY 216_ DPVHA 221_ APTTS 226_ TRVFY 231_ ISVGV 236_ CCAVI 241_ FLVAI 246_ ILAVL 251_ HLHSM 256_ KRIEL 261_ DDSIS 266_ ASSSS 271_ QGLSQ 276_ PSTQT 281_ TQYLR 286_ ADTPN 291_ NATPI 296_ TSYPT 301_ LRIEK 306_ NDLRS 311_ VTLLE 316_ AKGKV 321_ KDIAI 326_ SRERI 331_ TLKDV 336_ LQEGT 341_ FGRIF 346_ HGILI 351_ DEKDP 356_ NKEKQ 361_ AFVKT 366_ VKDQA 371_ SEIQV 376_ TMMLT 381_ ESCKL 386_ RGLHH 391_ RNLLP 396_ ITHVC 401_ IEEGE 406_ KPMVI 411_ LPYMN 416_ WGNLK 421_ LFLRQ 426_ CKLVE 431_ ANNPQ 436_ AISQQ 441_ DLVHM 446_ AIQIA 451_ CGMSY 456_ LARRE 461_ VIHKD 466_ LAARN 471_ CVIDD 476_ TLQVK 481_ ITDNA 486_ LSRDL 491_ FPMDY 496_ HCLGD 501_ NENRP 506_ VRWMA 511_ LESLV 516_ NNEFS 521_ SASDV 526_ WAFGV 531_ TLWEL 536_ MTLGQ 541_ TPYVD 546_ IDPFE 551_ MAAYL 556_ KDGYR 561_ IAQPI 566_ NCPDE 571_ LFAVM 576_ ACCWA 581_ LDPEE 586_ RPKFQ 591_ QLVQC 596_ LTEFH 601_AALGA
1: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development