Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
1_MGGHP 6_ QLRLV 11_ KALLL 16_ LGLNP 21_ VSASL 26_ QDQHC 31_ ESLSL 36_ ASNIS 41_ GLQCN 46_ ASVDL 51_ IGTCW 56_ PRSPA 61_ GQLVV 66_ RPCPA 71_ FFYGV 76_ RYNTT 81_ NNGYR 86_ ECLAN 91_ GSWAA 96_ RVNYS 101_ ECQEI 106_ LNEEK 111_ KSKVH 116_ YHVAV 121_ IINYL 126_ GHCIS 131_ LVALL 136_ VAFVL 141_ FLRLR 146_ PGCTH 151_ WGDQA 156_ DGALE 161_ VGAPW 166_ SGAPF 171_ QVRRS 176_ IRCLR 181_ NIIHW 186_ NLISA 191_ FILRN 196_ ATWFV 201_ VQLTM 206_ SPEVH 211_ QSNVG 216_ WCRLV 221_ TAAYN 226_ YFHVT 231_ NFFWM 236_ FGEGC 241_ YLHTA 246_ IVLTY 251_ STDRL 256_ RKWMF 261_ ICIGW 266_ GVPFP 271_ IIVAW 276_ AIGKL 281_ YYDNE 286_ KCWFG 291_ KRPGV 296_ YTDYI 301_ YQGPM 306_ ILVLL 311_ INFIF 316_ LFNIV 321_ RILMT 326_ KLRAS 331_ TTSET 336_ IQYRK 341_ AVKAT 346_ LVLLP 351_ LLGIT 356_ YMLFF 361_ VNPGE 366_ DEVSR 371_ VVFIY 376_ FNSFL 381_ ESFQG 386_ FFVSV 391_ FYCFL 396_ NSEVR 401_ SAIRK 406_ RWHRW 411_ QDKHS 416_ IRARV 421_ ARAMS 426_ IPTSP 431_ TRVSF 436_HSIKQ
1: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli