Gene name: PFN2

Uniprot entry:

P35080

Protein names:

Profilin-2 (Profilin II)

Protein sequence:

1_MAGWQ 6_ SYVDN 11_ LMCDG 16_ CCQEA 21_ AIVGY 26_ CDAKY 31_ VWAAT 36_ AGGVF 41_ QSITP 46_ IEIDM 51_ IVGKD 56_ REGFF 61_ TNGLT 66_ LGAKK 71_ CSVIR 76_ DSLYV 81_ DGDCT 86_ MDIRT 91_ KSQGG 96_ EPTYN 101_ VAVGR 106_ AGRVL 111_ VFVMG 116_ KEGVH 121_ GGGLN 126_ KKAYS 131_MAKYL

Protein annotations

Protein functions:

1: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG