Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)
1_MDMVE 6_ NADSL 11_ QAQER 16_ KDILM 21_ KYDKG 26_ HRAGL 31_ PEDKG 36_ PEPVG 41_ INSSI 46_ DRFGI 51_ LHETE 56_ LPPVT 61_ AREAK 66_ KIRRE 71_ MTRTS 76_ KWMEM 81_ LGEWE 86_ TYKHS 91_ SKLID 96_ RVYKG 101_ IPMNI 106_ RGPVW 111_ SVLLN 116_ IQEIK 121_ LKNPG 126_ RYQIM 131_ KERGK 136_ RSSEH 141_ IHHID 146_ LDVRT 151_ TLRNH 156_ VFFRD 161_ RYGAK 166_ QRELF 171_ YILLA 176_ YSEYN 181_ PEVGY 186_ CRDLS 191_ HITAL 196_ FLLYL 201_ PEEDA 206_ FWALV 211_ QLLAS 216_ ERHSL 221_ PGFHS 226_ PNGGT 231_ VQGLQ 236_ DQQEH 241_ VVPKS 246_ QPKTM 251_ WHQDK 256_ EGLCG 261_ QCASL 266_ GCLLR 271_ NLIDG 276_ ISLGL 281_ TLRLW 286_ DVYLV 291_ EGEQV 296_ LMPIT 301_ SIALK 306_ VQQKR 311_ LMKTS 316_ RCGLW 321_ ARLRN 326_ QFFDT 331_ WAMND 336_ DTVLK 341_ HLRAS 346_ TKKLT 351_ RKQGD 356_ LPPPA 361_ KREQG 366_ SLAPR 371_ PVPAS 376_ RGGKT 381_ LCKGY 386_ RQAPP 391_ GPPAQ 396_ FQRPI 401_ CSASP 406_ PWASR 411_ FSTPC 416_ PGGAV 421_ REDTY 426_ PVGTQ 431_ GVPSL 436_ ALAQG 441_ GPQGS 446_ WRFLE 451_ WKSMP 456_ RLPTD 461_ LDIGG 466_ PWFPH 471_ YDFEW 476_ SCWVR 481_ AISQE 486_ DQLAT 491_ CWQAE 496_ HCGEV 501_ HNKDM 506_ SWPEE 511_ MSFTA 516_ NSSKI 521_ DRQKV 526_ PTEKG 531_ ATGLS 536_ NLGNT 541_ CFMNS 546_ SIQCV 551_ SNTQP 556_ LTQYF 561_ ISGRH 566_ LYELN 571_ RTNPI 576_ GMKGH 581_ MAKCY 586_ GDLVQ 591_ ELWSG 596_ TQKSV 601_ APLKL 606_ RRTIA 611_ KYAPK 616_ FDGFQ 621_ QQDSQ 626_ ELLAF 631_ LLDGL 636_ HEDLN 641_ RVHEK 646_ PYVEL 651_ KDSDG 656_ RPDWE 661_ VAAEA 666_ WDNHL 671_ RRNRS 676_ IIVDL 681_ FHGQL 686_ RSQVK 691_ CKTCG 696_ HISVR 701_ FDPFN 706_ FLSLP 711_ LPMDS 716_ YMDLE 721_ ITVIK 726_ LDGTT 731_ PVRYG 736_ LRLNM 741_ DEKYT 746_ GLKKQ 751_ LRDLC 756_ GLNSE 761_ QILLA 766_ EVHDS 771_ NIKNF 776_ PQDNQ 781_ KVQLS 786_ VSGFL 791_ CAFEI 796_ PVPSS 801_ PISAS 806_ SPTQI 811_ DFSSS 816_ PSTNG 821_ MFTLT 826_ TNGDL 831_ PKPIF 836_ IPNGM 841_ PNTVV 846_ PCGTE 851_ KNFTN 856_ GMVNG 861_ HMPSL 866_ PDSPF 871_ TGYII 876_ AVHRK 881_ MMRTE 886_ LYFLS 891_ PQENR 896_ PSLFG 901_ MPLIV 906_ PCTVH 911_ TRKKD 916_ LYDAV 921_ WIQVS 926_ WLARP 931_ LPPQE 936_ ASIHA 941_ QDRDN 946_ CMGYQ 951_ YPFTL 956_ RVVQK 961_ DGNSC 966_ AWCPQ 971_ YRFCR 976_ GCKID 981_ CGEDR 986_ AFIGN 991_ AYIAV 996_ DWHPT 1001_ ALHLR 1006_ YQTSQ 1011_ ERVVD 1016_ KHESV 1021_ EQSRR 1026_ AQAEP 1031_ INLDS 1036_ CLRAF 1041_ TSEEE 1046_ LGESE 1051_ MYYCS 1056_ KCKTH 1061_ CLATK 1066_ KLDLW 1071_ RLPPF 1076_ LIIHL 1081_ KRFQF 1086_ VNDQW 1091_ IKSQK 1096_ IVRFL 1101_ RESFD 1106_ PSAFL 1111_ VPRDP 1116_ ALCQH 1121_ KPLTP 1126_ QGDEL 1131_ SKPRI 1136_ LAREV 1141_ KKVDA 1146_ QSSAG 1151_ KEDML 1156_ LSKSP 1161_ SSLSA 1166_ NISSS 1171_ PKGSP 1176_ SSSRK 1181_ SGTSC 1186_ PSSKN 1191_ SSPNS 1196_ SPRTL 1201_ GRSKG 1206_ RLRLP 1211_ QIGSK 1216_ NKPSS 1221_ SKKNL 1226_ DASKE 1231_ NGAGQ 1236_ ICELA 1241_ DALSR 1246_ GHMRG 1251_ GSQPE 1256_ LVTPQ 1261_ DHEVA 1266_ LANGF 1271_ LYEHE 1276_ ACGNG 1281_ CGDGY 1286_ SNGQL 1291_ GNHSE 1296_ EDSTD 1301_ DQRED 1306_ THIKP 1311_ IYNLY 1316_ AISCH 1321_ SGILS 1326_ GGHYI 1331_ TYAKN 1336_ PNCKW 1341_ YCYND 1346_ SSCEE 1351_ LHPDE 1356_ IDTDS 1361_ AYILF 1366_ YEQQG 1371_ IDYAQ 1376_ FLPKI 1381_ DGKKM 1386_ ADTSS 1391_ TDEDS 1396_ ESDYE 1401_KYSML
1: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A (PubMed:19077034)