Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)
1_MTAVH 6_ AGNIN 11_ FKWDP 16_ KSLEI 21_ RTLAV 26_ ERLLE 31_ PLVTQ 36_ VTTLV 41_ NTNSK 46_ GPSNK 51_ KRGRS 56_ KKAHV 61_ LAASV 66_ EQATE 71_ NFLEK 76_ GDKIA 81_ KESQF 86_ LKEEL 91_ VAAVE 96_ DVRKQ 101_ GDLMK 106_ AAAGE 111_ FADDP 116_ CSSVK 121_ RGNMV 126_ RAARA 131_ LLSAV 136_ TRLLI 141_ LADMA 146_ DVYKL 151_ LVQLK 156_ VVEDG 161_ ILKLR 166_ NAGNE 171_ QDLGI 176_ QYKAL 181_ KPEVD 186_ KLNIM 191_ AAKRQ 196_ QELKD 201_ VGHRD 206_ QMAAA 211_ RGILQ 216_ KNVPI 221_ LYTAS 226_ QACLQ 231_ HPDVA 236_ AYKAN 241_ RDLIY 246_ KQLQQ 251_ AVTGI 256_ SNAAQ 261_ ATASD 266_ DASQH 271_ QGGGG 276_ GELAY 281_ ALNNF 286_ DKQII 291_ VDPLS 296_ FSEER 301_ FRPSL 306_ EERLE 311_ SIISG 316_ AALMA 321_ DSSCT 326_ RDDRR 331_ ERIVA 336_ ECNAV 341_ RQALQ 346_ DLLSE 351_ YMGNA 356_ GRKER 361_ SDALN 366_ SAIDK 371_ MTKKT 376_ RDLRR 381_ QLRKA 386_ VMDHV 391_ SDSFL 396_ ETNVP 401_ LLVLI 406_ EAAKN 411_ GNEKE 416_ VKEYA 421_ QVFRE 426_ HANKL 431_ IEVAN 436_ LACSI 441_ SNNEE 446_ GVKLV 451_ RMSAS 456_ QLEAL 461_ CPQVI 466_ NAALA 471_ LAAKP 476_ QSKLA 481_ QENMD 486_ LFKEQ 491_ WEKQV 496_ RVLTD 501_ AVDDI 506_ TSIDD 511_ FLAVS 516_ ENHIL 521_ EDVNK 526_ CVIAL 531_ QEKDV 536_ DGLDR 541_ TAGAI 546_ RGRAA 551_ RVIHV 556_ VTSEM 561_ DNYEP 566_ GVYTE 571_ KVLEA 576_ TKLLS 581_ NTVMP 586_ RFTEQ 591_ VEAAV 596_ EALSS 601_ DPAQP 606_ MDENE 611_ FIDAS 616_ RLVYD 621_ GIRDI 626_ RKAVL 631_ MIRTP 636_ EELDD 641_ SDFET 646_ EDFDV 651_ RSRTS 656_ VQTED 661_ DQLIA 666_ GQSAR 671_ AIMAQ 676_ LPQEQ 681_ KAKIA 686_ EQVAS 691_ FQEEK 696_ SKLDA 701_ EVSKW 706_ DDSGN 711_ DIIVL 716_ AKQMC 721_ MIMME 726_ MTDFT 731_ RGKGP 736_ LKNTS 741_ DVISA 746_ AKKIA 751_ EAGSR 756_ MDKLG 761_ RTIAD 766_ HCPDS 771_ ACKQD 776_ LLAYL 781_ QRIAL 786_ YCHQL 791_ NICSK 796_ VKAEV 801_ QNLGG 806_ ELVVS 811_ GVDSA 816_ MSLIQ 821_ AAKNL 826_ MNAVV 831_ QTVKA 836_ SYVAS 841_ TKYQK 846_ SQGMA 851_ SLNLP 856_ AVSWK 861_ MKAPE 866_ KKPLV 871_ KREKQ 876_ DETQT 881_ KIKRA 886_ SQKKH 891_ VNPVQ 896_ ALSEF 901_KAMDS
1: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation