Catenin beta-1 (Beta-catenin)
1_MATQA 6_ DLMEL 11_ DMAME 16_ PDRKA 21_ AVSHW 26_ QQQSY 31_ LDSGI 36_ HSGAT 41_ TTAPS 46_ LSGKG 51_ NPEEE 56_ DVDTS 61_ QVLYE 66_ WEQGF 71_ SQSFT 76_ QEQVA 81_ DIDGQ 86_ YAMTR 91_ AQRVR 96_ AAMFP 101_ ETLDE 106_ GMQIP 111_ STQFD 116_ AAHPT 121_ NVQRL 126_ AEPSQ 131_ MLKHA 136_ VVNLI 141_ NYQDD 146_ AELAT 151_ RAIPE 156_ LTKLL 161_ NDEDQ 166_ VVVNK 171_ AAVMV 176_ HQLSK 181_ KEASR 186_ HAIMR 191_ SPQMV 196_ SAIVR 201_ TMQNT 206_ NDVET 211_ ARCTA 216_ GTLHN 221_ LSHHR 226_ EGLLA 231_ IFKSG 236_ GIPAL 241_ VKMLG 246_ SPVDS 251_ VLFYA 256_ ITTLH 261_ NLLLH 266_ QEGAK 271_ MAVRL 276_ AGGLQ 281_ KMVAL 286_ LNKTN 291_ VKFLA 296_ ITTDC 301_ LQILA 306_ YGNQE 311_ SKLII 316_ LASGG 321_ PQALV 326_ NIMRT 331_ YTYEK 336_ LLWTT 341_ SRVLK 346_ VLSVC 351_ SSNKP 356_ AIVEA 361_ GGMQA 366_ LGLHL 371_ TDPSQ 376_ RLVQN 381_ CLWTL 386_ RNLSD 391_ AATKQ 396_ EGMEG 401_ LLGTL 406_ VQLLG 411_ SDDIN 416_ VVTCA 421_ AGILS 426_ NLTCN 431_ NYKNK 436_ MMVCQ 441_ VGGIE 446_ ALVRT 451_ VLRAG 456_ DREDI 461_ TEPAI 466_ CALRH 471_ LTSRH 476_ QEAEM 481_ AQNAV 486_ RLHYG 491_ LPVVV 496_ KLLHP 501_ PSHWP 506_ LIKAT 511_ VGLIR 516_ NLALC 521_ PANHA 526_ PLREQ 531_ GAIPR 536_ LVQLL 541_ VRAHQ 546_ DTQRR 551_ TSMGG 556_ TQQQF 561_ VEGVR 566_ MEEIV 571_ EGCTG 576_ ALHIL 581_ ARDVH 586_ NRIVI 591_ RGLNT 596_ IPLFV 601_ QLLYS 606_ PIENI 611_ QRVAA 616_ GVLCE 621_ LAQDK 626_ EAAEA 631_ IEAEG 636_ ATAPL 641_ TELLH 646_ SRNEG 651_ VATYA 656_ AAVLF 661_ RMSED 666_ KPQDY 671_ KKRLS 676_ VELTS 681_ SLFRT 686_ EPMAW 691_ NETAD 696_ LGLDI 701_ GAQGE 706_ PLGYR 711_ QDDPS 716_ YRSFH 721_ SGGYG 726_ QDALG 731_ MDPMM 736_ EHEMG 741_ GHHPG 746_ ADYPV 751_ DGLPD 756_ LGHAQ 761_ DLMDG 766_ LPPGD 771_ SNQLA 776_WFDTD
1: Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity)