Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
1_MHRTT 6_ RIKIT 11_ ELNPH 16_ LMCVL 21_ CGGYF 26_ IDATT 31_ IIECL 36_ HSFCK 41_ TCIVR 46_ YLETS 51_ KYCPI 56_ CDVQV 61_ HKTRP 66_ LLNIR 71_ SDKTL 76_ QDIVY 81_ KLVPG 86_ LFKNE 91_ MKRRR 96_ DFYAA 101_ HPSAD 106_ AANGS 111_ NEDRG 116_ EVADE 121_ DKRII 126_ TDDEI 131_ ISLSI 136_ EFFDQ 141_ NRLDR 146_ KVNKD 151_ KEKSK 156_ EEVND 161_ KRYLR 166_ CPAAM 171_ TVMHL 176_ RKFLR 181_ SKMDI 186_ PNTFQ 191_ IDVMY 196_ EEEPL 201_ KDYYT 206_ LMDIA 211_ YIYTW 216_ RRNGP 221_ LPLKY 226_ RVRPT 231_ CKRMK 236_ ISHQR 241_ DGLTN 246_ AGELE 251_ SDSGS 256_ DKANS 261_ PAGGI 266_ PSTSS 271_ CLPSP 276_ STPVQ 281_ SPHPQ 286_ FPHIS 291_ STMNG 296_ TSNSP 301_ SGNHQ 306_ SSFAN 311_ RPRKS 316_ SVNGS 321_SATSS
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332)