Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
1_MHRTT 6_ RIKIT 11_ ELNPH 16_ LMCAL 21_ CGGYF 26_ IDATT 31_ IVECL 36_ HSFCK 41_ TCIVR 46_ YLETN 51_ KYCPM 56_ CDVQV 61_ HKTRP 66_ LLSIR 71_ SDKTL 76_ QDIVY 81_ KLVPG 86_ LFKDE 91_ MKRRR 96_ DFYAA 101_ YPLTE 106_ VPNGS 111_ NEDRG 116_ EVLEQ 121_ EKGAL 126_ SDDEI 131_ VSLSI 136_ EFYEG 141_ ARDRD 146_ EKKGP 151_ LENGD 156_ GDKEK 161_ TGVRF 166_ LRCPA 171_ AMTVM 176_ HLAKF 181_ LRNKM 186_ DVPSK 191_ YKVEV 196_ LYEDE 201_ PLKEY 206_ YTLMD 211_ IAYIY 216_ PWRRN 221_ GPLPL 226_ KYRVQ 231_ PACKR 236_ LTLAT 241_ VPTPS 246_ EGTNT 251_ SGASE 256_ CESVS 261_ DKAPS 266_ PATLP 271_ ATSSS 276_ LPSPA 281_ TPSHG 286_ SPSSH 291_ GPPAT 296_ HPTSP 301_ TPPST 306_ ASGAT 311_ TAANG 316_ GSLNC 321_ LQTPS 326_ STSRG 331_ RKMTV 336_NGAPV
1: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332)