Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
1_MACPW 6_ KFLFK 11_ TKFHQ 16_ YAMNG 21_ EKDIN 26_ NNVEK 31_ APCAT 36_ SSPVT 41_ QDDLQ 46_ YHNLS 51_ KQQNE 56_ SPQPL 61_ VETGK 66_ KSPES 71_ LVKLD 76_ ATPLS 81_ SPRHV 86_ RIKNW 91_ GSGMT 96_ FQDTL 101_ HHKAK 106_ GILTC 111_ RSKSC 116_ LGSIM 121_ TPKSL 126_ TRGPR 131_ DKPTP 136_ PDELL 141_ PQAIE 146_ FVNQY 151_ YGSFK 156_ EAKIE 161_ EHLAR 166_ VEAVT 171_ KEIET 176_ TGTYQ 181_ LTGDE 186_ LIFAT 191_ KQAWR 196_ NAPRC 201_ IGRIQ 206_ WSNLQ 211_ VFDAR 216_ SCSTA 221_ REMFE 226_ HICRH 231_ VRYST 236_ NNGNI 241_ RSAIT 246_ VFPQR 251_ SDGKH 256_ DFRVW 261_ NAQLI 266_ RYAGY 271_ QMPDG 276_ SIRGD 281_ PANVE 286_ FTQLC 291_ IDLGW 296_ KPKYG 301_ RFDVV 306_ PLVLQ 311_ ANGRD 316_ PELFE 321_ IPPDL 326_ VLEVA 331_ MEHPK 336_ YEWFR 341_ ELELK 346_ WYALP 351_ AVANM 356_ LLEVG 361_ GLEFP 366_ GCPFN 371_ GWYMG 376_ TEIGV 381_ RDFCD 386_ VQRYN 391_ ILEEV 396_ GRRMG 401_ LETHK 406_ LASLW 411_ KDQAV 416_ VEINI 421_ AVLHS 426_ FQKQN 431_ VTIMD 436_ HHSAA 441_ ESFMK 446_ YMQNE 451_ YRSRG 456_ GCPAD 461_ WIWLV 466_ PPMSG 471_ SITPV 476_ FHQEM 481_ LNYVL 486_ SPFYY 491_ YQVEA 496_ WKTHV 501_ WQDEK 506_ RRPKR 511_ REIPL 516_ KVLVK 521_ AVLFA 526_ CMLMR 531_ KTMAS 536_ RVRVT 541_ ILFAT 546_ ETGKS 551_ EALAW 556_ DLGAL 561_ FSCAF 566_ NPKVV 571_ CMDKY 576_ RLSCL 581_ EEERL 586_ LLVVT 591_ STFGN 596_ GDCPG 601_ NGEKL 606_ KKSLF 611_ MLKEL 616_ NNKFR 621_ YAVFG 626_ LGSSM 631_ YPRFC 636_ AFAHD 641_ IDQKL 646_ SHLGA 651_ SQLTP 656_ MGEGD 661_ ELSGQ 666_ EDAFR 671_ SWAVQ 676_ TFKAA 681_ CETFD 686_ VRGKQ 691_ HIQIP 696_ KLYTS 701_ NVTWD 706_ PHHYR 711_ LVQDS 716_ QPLDL 721_ SKALS 726_ SMHAK 731_ NVFTM 736_ RLKSR 741_ QNLQS 746_ PTSSR 751_ ATILV 756_ ELSCE 761_ DGQGL 766_ NYLPG 771_ EHLGV 776_ CPGNQ 781_ PALVQ 786_ GILER 791_ VVDGP 796_ TPHQT 801_ VRLEA 806_ LDESG 811_ SYWVS 816_ DKRLP 821_ PCSLS 826_ QALTY 831_ FLDIT 836_ TPPTQ 841_ LLLQK 846_ LAQVA 851_ TEEPE 856_ RQRLE 861_ ALCQP 866_ SEYSK 871_ WKFTN 876_ SPTFL 881_ EVLEE 886_ FPSLR 891_ VSAGF 896_ LLSQL 901_ PILKP 906_ RFYSI 911_ SSSRD 916_ HTPTE 921_ IHLTV 926_ AVVTY 931_ HTRDG 936_ QGPLH 941_ HGVCS 946_ TWLNS 951_ LKPQD 956_ PVPCF 961_ VRNAS 966_ GFHLP 971_ EDPSH 976_ PCILI 981_ GPGTG 986_ IAPFR 991_ SFWQQ 996_ RLHDS 1001_ QHKGV 1006_ RGGRM 1011_ TLVFG 1016_ CRRPD 1021_ EDHIY 1026_ QEEML 1031_ EMAQK 1036_ GVLHA 1041_ VHTAY 1046_ SRLPG 1051_ KPKVY 1056_ VQDIL 1061_ RQQLA 1066_ SEVLR 1071_ VLHKE 1076_ PGHLY 1081_ VCGDV 1086_ RMARD 1091_ VAHTL 1096_ KQLVA 1101_ AKLKL 1106_ NEEQV 1111_ EDYFF 1116_ QLKSQ 1121_ KRYHE 1126_ DIFGA 1131_ VFPYE 1136_ AKKDR 1141_ VAVQP 1146_SSLEM
1: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109)