Prohibitin 1
1_MAAKV 6_ FESIG 11_ KFGLA 16_ LAVAG 21_ GVVNS 26_ ALYNV 31_ DAGHR 36_ AVIFD 41_ RFRGV 46_ QDIVV 51_ GEGTH 56_ FLIPW 61_ VQKPI 66_ IFDCR 71_ SRPRN 76_ VPVIT 81_ GSKDL 86_ QNVNI 91_ TLRIL 96_ FRPVA 101_ SQLPR 106_ IFTSI 111_ GEDYD 116_ ERVLP 121_ SITTE 126_ ILKSV 131_ VARFD 136_ AGELI 141_ TQREL 146_ VSRQV 151_ SDDLT 156_ ERAAT 161_ FGLIL 166_ DDVSL 171_ THLTF 176_ GKEFT 181_ EAVEA 186_ KQVAQ 191_ QEAER 196_ ARFVV 201_ EKAEQ 206_ QKKAA 211_ IISAE 216_ GDSKA 221_ AELIA 226_ NSLAT 231_ AGDGL 236_ IELRK 241_ LEAAE 246_ DIAYQ 251_ LSRSR 256_ NITYL 261_ PAGQS 266_VLLQL
1: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity)
2: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117)
3: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195)
4: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)