Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
1_MAGAI 6_ ASRMS 11_ FSSLK 16_ RKQPK 21_ TFTVR 26_ IVTMD 31_ AEMEF 36_ NCEMK 41_ WKGKD 46_ LFDLV 51_ CRTLG 56_ LRETW 61_ FFGLQ 66_ YTIKD 71_ TVAWL 76_ KMDKK 81_ VLDHD 86_ VSKEE 91_ PVTFH 96_ FLAKF 101_ YPENA 106_ EEELV 111_ QEITQ 116_ HLFFL 121_ QVKKQ 126_ ILDEK 131_ IYCPP 136_ EASVL 141_ LASYA 146_ VQAKY 151_ GDYDP 156_ SVHKR 161_ GFLAQ 166_ EELLP 171_ KRVIN 176_ LYQMT 181_ PEMWE 186_ ERITA 191_ WYAEH 196_ RGRAR 201_ DEAEM 206_ EYLKI 211_ AQDLE 216_ MYGVN 221_ YFAIR 226_ NKKGT 231_ ELLLG 236_ VDALG 241_ LHIYD 246_ PENRL 251_ TPKIS 256_ FPWNE 261_ IRNIS 266_ YSDKE 271_ FTIKP 276_ LDKKI 281_ DVFKF 286_ NSSKL 291_ RVNKL 296_ ILQLC 301_ IGNHD 306_ LFMRR 311_ RKADS 316_ LEVQQ 321_ MKAQA 326_ REEKA 331_ RKQME 336_ RQRLA 341_ REKQM 346_ REEAE 351_ RTRDE 356_ LERRL 361_ LQMKE 366_ EATMA 371_ NEALM 376_ RSEET 381_ ADLLA 386_ EKAQI 391_ TEEEA 396_ KLLAQ 401_ KAAEA 406_ EQEMQ 411_ RIKAT 416_ AIRTE 421_ EEKRL 426_ MEQKV 431_ LEAEV 436_ LALKM 441_ AEESE 446_ RRAKE 451_ ADQLK 456_ QDLQE 461_ AREAE 466_ RRAKQ 471_ KLLEI 476_ ATKPT 481_ YPPMN 486_ PIPAP 491_ LPPDI 496_ PSFNL 501_ IGDSL 506_ SFDFK 511_ DTDMK 516_ RLSME 521_ IEKEK 526_ VEYME 531_ KSKHL 536_ QEQLN 541_ ELKTE 546_ IEALK 551_ LKERE 556_ TALDI 561_ LHNEN 566_ SDRGG 571_ SSKHN 576_ TIKKL 581_ TLQSA 586_KSRVA
1: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex