Small proline-rich protein 2A (SPR-2A) (2-1)
1_MSYQQ 6_ QQCKQ 11_ PCQPP 16_ PVCPT 21_ PKCPE 26_ PCPPP 31_ KCPEP 36_ CPPPK 41_ CPQPC 46_ PPQQC 51_ QQKYP 56_ PVTPS 61_ PPCQS 66_KYPPK
1: Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635)