Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)
1_MEQTV 6_ LVPPG 11_ PDSFN 16_ FFTRE 21_ SLAAI 26_ ERRIA 31_ EEKAK 36_ NPKPD 41_ KKDDD 46_ ENGPK 51_ PNSDL 56_ EAGKN 61_ LPFIY 66_ GDIPP 71_ EMVSE 76_ PLEDL 81_ DPYYI 86_ NKKTF 91_ IVLNK 96_ GKAIF 101_ RFSAT 106_ SALYI 111_ LTPFN 116_ PLRKI 121_ AIKIL 126_ VHSLF 131_ SMLIM 136_ CTILT 141_ NCVFM 146_ TMSNP 151_ PDWTK 156_ NVEYT 161_ FTGIY 166_ TFESL 171_ IKIIA 176_ RGFCL 181_ EDFTF 186_ LRDPW 191_ NWLDF 196_ TVITF 201_ AYVTE 206_ FVDLG 211_ NVSAL 216_ RTFRV 221_ LRALK 226_ TISVI 231_ PGLKT 236_ IVGAL 241_ IQSVK 246_ KLSDV 251_ MILTV 256_ FCLSV 261_ FALIG 266_ LQLFM 271_ GNLRN 276_ KCIQW 281_ PPTNA 286_ SLEEH 291_ SIEKN 296_ ITVNY 301_ NGTLI 306_ NETVF 311_ EFDWK 316_ SYIQD 321_ SRYHY 326_ FLEGF 331_ LDALL 336_ CGNSS 341_ DAGQC 346_ PEGYM 351_ CVKAG 356_ RNPNY 361_ GYTSF 366_ DTFSW 371_ AFLSL 376_ FRLMT 381_ QDFWE 386_ NLYQL 391_ TLRAA 396_ GKTYM 401_ IFFVL 406_ VIFLG 411_ SFYLI 416_ NLILA 421_ VVAMA 426_ YEEQN 431_ QATLE 436_ EAEQK 441_ EAEFQ 446_ QMIEQ 451_ LKKQQ 456_ EAAQQ 461_ AATAT 466_ ASEHS 471_ REPSA 476_ AGRLS 481_ DSSSE 486_ ASKLS 491_ SKSAK 496_ ERRNR 501_ RKKRK 506_ QKEQS 511_ GGEEK 516_ DEDEF 521_ QKSES 526_ EDSIR 531_ RKGFR 536_ FSIEG 541_ NRLTY 546_ EKRYS 551_ SPHQS 556_ LLSIR 561_ GSLFS 566_ PRRNS 571_ RTSLF 576_ SFRGR 581_ AKDVG 586_ SENDF 591_ ADDEH 596_ STFED 601_ NESRR 606_ DSLFV 611_ PRRHG 616_ ERRNS 621_ NLSQT 626_ SRSSR 631_ MLAVF 636_ PANGK 641_ MHSTV 646_ DCNGV 651_ VSLVG 656_ GPSVP 661_ TSPVG 666_ QLLPE 671_ VIIDK 676_ PATDD 681_ NGTTT 686_ ETEMR 691_ KRRSS 696_ SFHVS 701_ MDFLE 706_ DPSQR 711_ QRAMS 716_ IASIL 721_ TNTVE 726_ ELEES 731_ RQKCP 736_ PCWYK 741_ FSNIF 746_ LIWDC 751_ SPYWL 756_ KVKHV 761_ VNLVV 766_ MDPFV 771_ DLAIT 776_ ICIVL 781_ NTLFM 786_ AMEHY 791_ PMTDH 796_ FNNVL 801_ TVGNL 806_ VFTGI 811_ FTAEM 816_ FLKII 821_ AMDPY 826_ YYFQE 831_ GWNIF 836_ DGFIV 841_ TLSLV 846_ ELGLA 851_ NVEGL 856_ SVLRS 861_ FRLLR 866_ VFKLA 871_ KSWPT 876_ LNMLI 881_ KIIGN 886_ SVGAL 891_ GNLTL 896_ VLAII 901_ VFIFA 906_ VVGMQ 911_ LFGKS 916_ YKDCV 921_ CKIAS 926_ DCQLP 931_ RWHMN 936_ DFFHS 941_ FLIVF 946_ RVLCG 951_ EWIET 956_ MWDCM 961_ EVAGQ 966_ AMCLT 971_ VFMMV 976_ MVIGN 981_ LVVLN 986_ LFLAL 991_ LLSSF 996_ SADNL 1001_ AATDD 1006_ DNEMN 1011_ NLQIA 1016_ VDRMH 1021_ KGVAY 1026_ VKRKI 1031_ YEFIQ 1036_ QSFIR 1041_ KQKIL 1046_ DEIKP 1051_ LDDLN 1056_ NKKDS 1061_ CMSNH 1066_ TAEIG 1071_ KDLDY 1076_ LKDVN 1081_ GTTSG 1086_ IGTGS 1091_ SVEKY 1096_ IIDES 1101_ DYMSF 1106_ INNPS 1111_ LTVTV 1116_ PIAVG 1121_ ESDFE 1126_ NLNTE 1131_ DFSSE 1136_ SDLEE 1141_ SKEKL 1146_ NESSS 1151_ SSEGS 1156_ TVDIG 1161_ APVEE 1166_ QPVVE 1171_ PEETL 1176_ EPEAC 1181_ FTEGC 1186_ VQRFK 1191_ CCQIN 1196_ VEEGR 1201_ GKQWW 1206_ NLRRT 1211_ CFRIV 1216_ EHNWF 1221_ ETFIV 1226_ FMILL 1231_ SSGAL 1236_ AFEDI 1241_ YIDQR 1246_ KTIKT 1251_ MLEYA 1256_ DKVFT 1261_ YIFIL 1266_ EMLLK 1271_ WVAYG 1276_ YQTYF 1281_ TNAWC 1286_ WLDFL 1291_ IVDVS 1296_ LVSLT 1301_ ANALG 1306_ YSELG 1311_ AIKSL 1316_ RTLRA 1321_ LRPLR 1326_ ALSRF 1331_ EGMRV 1336_ VVNAL 1341_ LGAIP 1346_ SIMNV 1351_ LLVCL 1356_ IFWLI 1361_ FSIMG 1366_ VNLFA 1371_ GKFYH 1376_ CINTT 1381_ TGDRF 1386_ DIEDV 1391_ NNHTD 1396_ CLKLI 1401_ ERNET 1406_ ARWKN 1411_ VKVNF 1416_ DNVGF 1421_ GYLSL 1426_ LQVAT 1431_ FKGWM 1436_ DIMYA 1441_ AVDSR 1446_ NVELQ 1451_ PKYEE 1456_ SLYMY 1461_ LYFVI 1466_ FIIFG 1471_ SFFTL 1476_ NLFIG 1481_ VIIDN 1486_ FNQQK 1491_ KKFGG 1496_ QDIFM 1501_ TEEQK 1506_ KYYNA 1511_ MKKLG 1516_ SKKPQ 1521_ KPIPR 1526_ PGNKF 1531_ QGMVF 1536_ DFVTR 1541_ QVFDI 1546_ SIMIL 1551_ ICLNM 1556_ VTMMV 1561_ ETDDQ 1566_ SEYVT 1571_ TILSR 1576_ INLVF 1581_ IVLFT 1586_ GECVL 1591_ KLISL 1596_ RHYYF 1601_ TIGWN 1606_ IFDFV 1611_ VVILS 1616_ IVGMF 1621_ LAELI 1626_ EKYFV 1631_ SPTLF 1636_ RVIRL 1641_ ARIGR 1646_ ILRLI 1651_ KGAKG 1656_ IRTLL 1661_ FALMM 1666_ SLPAL 1671_ FNIGL 1676_ LLFLV 1681_ MFIYA 1686_ IFGMS 1691_ NFAYV 1696_ KREVG 1701_ IDDMF 1706_ NFETF 1711_ GNSMI 1716_ CLFQI 1721_ TTSAG 1726_ WDGLL 1731_ APILN 1736_ SKPPD 1741_ CDPNK 1746_ VNPGS 1751_ SVKGD 1756_ CGNPS 1761_ VGIFF 1766_ FVSYI 1771_ IISFL 1776_ VVVNM 1781_ YIAVI 1786_ LENFS 1791_ VATEE 1796_ SAEPL 1801_ SEDDF 1806_ EMFYE 1811_ VWEKF 1816_ DPDAT 1821_ QFMEF 1826_ EKLSQ 1831_ FAAAL 1836_ EPPLN 1841_ LPQPN 1846_ KLQLI 1851_ AMDLP 1856_ MVSGD 1861_ RIHCL 1866_ DILFA 1871_ FTKRV 1876_ LGESG 1881_ EMDAL 1886_ RIQME 1891_ ERFMA 1896_ SNPSK 1901_ VSYQP 1906_ ITTTL 1911_ KRKQE 1916_ EVSAV 1921_ IIQRA 1926_ YRRHL 1931_ LKRTV 1936_ KQASF 1941_ TYNKN 1946_ KIKGG 1951_ ANLLI 1956_ KEDMI 1961_ IDRIN 1966_ ENSIT 1971_ EKTDL 1976_ TMSTA 1981_ ACPPS 1986_ YDRVT 1991_ KPIVE 1996_ KHEQE 2001_GKDEK
1: Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14672992). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits (By similarity). Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (By similarity)