Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)
1_MARPS 6_ LCTLV 11_ PLGPE 16_ CLRPF 21_ TRESL 26_ AAIEQ 31_ RAVEE 36_ EARLQ 41_ RNKQM 46_ EIEEP 51_ ERKPR 56_ SDLEA 61_ GKNLP 66_ MIYGD 71_ PPPEV 76_ IGIPL 81_ EDLDP 86_ YYSNK 91_ KTFIV 96_ LNKGK 101_ AIFRF 106_ SATPA 111_ LYLLS 116_ PFSVV 121_ RRGAI 126_ KVLIH 131_ ALFSM 136_ FIMIT 141_ ILTNC 146_ VFMTM 151_ SDPPP 156_ WSKNV 161_ EYTFT 166_ GIYTF 171_ ESLIK 176_ ILARG 181_ FCVDD 186_ FTFLR 191_ DPWNW 196_ LDFSV 201_ IMMAY 206_ LTEFV 211_ DLGNI 216_ SALRT 221_ FRVLR 226_ ALKTI 231_ TVIPG 236_ LKTIV 241_ GALIQ 246_ SVKKL 251_ SDVMI 256_ LTVFC 261_ LSVFA 266_ LVGLQ 271_ LFMGN 276_ LRQKC 281_ VRWPP 286_ PFNDT 291_ NTTWY 296_ SNDTW 301_ YGNDT 306_ WYGNE 311_ MWYGN 316_ DSWYA 321_ NDTWN 326_ SHASW 331_ ATNDT 336_ FDWDA 341_ YISDE 346_ GNFYF 351_ LEGSN 356_ DALLC 361_ GNSSD 366_ AGHCP 371_ EGYEC 376_ IKTGR 381_ NPNYG 386_ YTSYD 391_ TFSWA 396_ FLALF 401_ RLMTQ 406_ DYWEN 411_ LFQLT 416_ LRAAG 421_ KTYMI 426_ FFVVI 431_ IFLGS 436_ FYLIN 441_ LILAV 446_ VAMAY 451_ AEQNE 456_ ATLAE 461_ DKEKE 466_ EEFQQ 471_ MLEKF 476_ KKHQE 481_ ELEKA 486_ KAAQA 491_ LEGGE 496_ ADGDP 501_ AHGKD 506_ CNGSL 511_ DTSQG 516_ EKGAP 521_ RQSSS 526_ GDSGI 531_ SDAME 536_ ELEEA 541_ HQKCP 546_ PWWYK 551_ CAHKV 556_ LIWNC 561_ CAPWL 566_ KFKNI 571_ IHLIV 576_ MDPFV 581_ DLGIT 586_ ICIVL 591_ NTLFM 596_ AMEHY 601_ PMTEH 606_ FDNVL 611_ TVGNL 616_ VFTGI 621_ FTAEM 626_ VLKLI 631_ AMDPY 636_ EYFQQ 641_ GWNIF 646_ DSIIV 651_ TLSLV 656_ ELGLA 661_ NVQGL 666_ SVLRS 671_ FRLLR 676_ VFKLA 681_ KSWPT 686_ LNMLI 691_ KIIGN 696_ SVGAL 701_ GNLTL 706_ VLAII 711_ VFIFA 716_ VVGMQ 721_ LFGKS 726_ YKECV 731_ CKIAL 736_ DCNLP 741_ RWHMH 746_ DFFHS 751_ FLIVF 756_ RILCG 761_ EWIET 766_ MWDCM 771_ EVAGQ 776_ AMCLT 781_ VFLMV 786_ MVIGN 791_ LVVLN 796_ LFLAL 801_ LLSSF 806_ SADSL 811_ AASDE 816_ DGEMN 821_ NLQIA 826_ IGRIK 831_ LGIGF 836_ AKAFL 841_ LGLLH 846_ GKILS 851_ PKDIM 856_ LSLGE 861_ ADGAG 866_ EAGEA 871_ GETAP 876_ EDEKK 881_ EPPEE 886_ DLKKD 891_ NHILN 896_ HMGLA 901_ DGPPS 906_ SLELD 911_ HLNFI 916_ NNPYL 921_ TIQVP 926_ IASEE 931_ SDLEM 936_ PTEEE 941_ TDTFS 946_ EPEDS 951_ KKPPQ 956_ PLYDG 961_ NSSVC 966_ STADY 971_ KPPEE 976_ DPEEQ 981_ AEENP 986_ EGEQP 991_ EECFT 996_ EACVQ 1001_ RWPCL 1006_ YVDIS 1011_ QGRGK 1016_ KWWTL 1021_ RRACF 1026_ KIVEH 1031_ NWFET 1036_ FIVFM 1041_ ILLSS 1046_ GALAF 1051_ EDIYI 1056_ EQRRV 1061_ IRTIL 1066_ EYADK 1071_ VFTYI 1076_ FIMEM 1081_ LLKWV 1086_ AYGFK 1091_ VYFTN 1096_ AWCWL 1101_ DFLIV 1106_ DVSII 1111_ SLVAN 1116_ WLGYS 1121_ ELGPI 1126_ KSLRT 1131_ LRALR 1136_ PLRAL 1141_ SRFEG 1146_ MRVVV 1151_ NALLG 1156_ AIPSI 1161_ MNVLL 1166_ VCLIF 1171_ WLIFS 1176_ IMGVN 1181_ LFAGK 1186_ FYYCI 1191_ NTTTS 1196_ ERFDI 1201_ SEVNN 1206_ KSECE 1211_ SLMHT 1216_ GQVRW 1221_ LNVKV 1226_ NYDNV 1231_ GLGYL 1236_ SLLQV 1241_ ATFKG 1246_ WMDIM 1251_ YAAVD 1256_ SREKE 1261_ EQPQY 1266_ EVNLY 1271_ MYLYF 1276_ VIFII 1281_ FGSFF 1286_ TLNLF 1291_ IGVII 1296_ DNFNQ 1301_ QKKKL 1306_ GGKDI 1311_ FMTEE 1316_ QKKYY 1321_ NAMKK 1326_ LGSKK 1331_ PQKPI 1336_ PRPQN 1341_ KIQGM 1346_ VYDLV 1351_ TKQAF 1356_ DITIM 1361_ ILICL 1366_ NMVTM 1371_ MVETD 1376_ NQSQL 1381_ KVDIL 1386_ YNINM 1391_ IFIII 1396_ FTGEC 1401_ VLKML 1406_ ALRQY 1411_ YFTVG 1416_ WNIFD 1421_ FVVVI 1426_ LSIVG 1431_ LALSD 1436_ LIQKY 1441_ FVSPT 1446_ LFRVI 1451_ RLARI 1456_ GRVLR 1461_ LIRGA 1466_ KGIRT 1471_ LLFAL 1476_ MMSLP 1481_ ALFNI 1486_ GLLLF 1491_ LVMFI 1496_ YSIFG 1501_ MSNFA 1506_ YVKKE 1511_ SGIDD 1516_ MFNFE 1521_ TFGNS 1526_ IICLF 1531_ EITTS 1536_ AGWDG 1541_ LLNPI 1546_ LNSGP 1551_ PDCDP 1556_ NLENP 1561_ GTSVK 1566_ GDCGN 1571_ PSIGI 1576_ CFFCS 1581_ YIIIS 1586_ FLIVV 1591_ NMYIA 1596_ IILEN 1601_ FNVAT 1606_ EESSE 1611_ PLGED 1616_ DFEMF 1621_ YETWE 1626_ KFDPD 1631_ ATQFI 1636_ AYSRL 1641_ SDFVD 1646_ TLQEP 1651_ LRIAK 1656_ PNKIK 1661_ LITLD 1666_ LPMVP 1671_ GDKIH 1676_ CLDIL 1681_ FALTK 1686_ EVLGD 1691_ SGEMD 1696_ ALKQT 1701_ MEEKF 1706_ MAANP 1711_ SKVSY 1716_ EPITT 1721_ TLKRK 1726_ HEEVC 1731_ AIKIQ 1736_ RAYRR 1741_ HLLQR 1746_ SMKQA 1751_ SYMYR 1756_ HSHDG 1761_ SGDDA 1766_ PEKEG 1771_ LLANT 1776_ MSKMY 1781_ GHENG 1786_ NSSSP 1791_ SPEEK 1796_ GEAGD 1801_ AGPTM 1806_ GLMPI 1811_ SPSDT 1816_ AWPPA 1821_ PPPGQ 1826_ TVRPG 1831_VKESL
1: Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:12766226, PubMed:15318338, PubMed:16890191, PubMed:17898326, PubMed:18690054, PubMed:19347921, PubMed:25707578, PubMed:26659129, PubMed:26700687, PubMed:29992740, PubMed:30190309). Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction (PubMed:16890191, PubMed:19347921, PubMed:25707578, PubMed:26659129, PubMed:26700687)