UDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A isoform 3)
1_MATGL 6_ QVPLP 11_ WLATG 16_ LLLLL 21_ SVQPW 26_ AESGK 31_ VLVVP 36_ IDGSH 41_ WLSMR 46_ EVLRE 51_ LHARG 56_ HQAVV 61_ LTPEV 66_ NMHIK 71_ EENFF 76_ TLTTY 81_ AISWT 86_ QDEFD 91_ RHVLG 96_ HTQLY 101_ FETEH 106_ FLKKF 111_ FRSMA 116_ MLNNM 121_ SLVYH 126_ RSCVE 131_ LLHNE 136_ ALIRH 141_ LNATS 146_ FDVVL 151_ TDPVN 156_ LCAAV 161_ LAKYL 166_ SIPTV 171_ FFLRN 176_ IPCDL 181_ DFKGT 186_ QCPNP 191_ SSYIP 196_ RLLTT 201_ NSDHM 206_ TFMQR 211_ VKNML 216_ YPLAL 221_ SYICH 226_ AFSAP 231_ YASLA 236_ SELFQ 241_ REVSV 246_ VDILS 251_ HASVW 256_ LFRGD 261_ FVMDY 266_ PRPIM 271_ PNMVF 276_ IGGIN 281_ CANRK 286_ PLSQE 291_ FEAYI 296_ NASGE 301_ HGIVV 306_ FSLGS 311_ MVSEI 316_ PEKKA 321_ MAIAD 326_ ALGKI 331_ PQTVL 336_ WRYTG 341_ TRPSN 346_ LANNT 351_ ILVKW 356_ LPQND 361_ LLGHP 366_ MTRAF 371_ ITHAG 376_ SHGVY 381_ ESICN 386_ GVPMV 391_ MMPLF 396_ GDQMD 401_ NAKRM 406_ ETKGA 411_ GVTLN 416_ VLEMT 421_ SEDLE 426_ NALKA 431_ VINDK 436_ SYKEN 441_ IMRLS 446_ SLHKD 451_ RPVEP 456_ LDLAV 461_ FWVEF 466_ VMRHK 471_ GAPHL 476_ RPAAH 481_ DLTWY 486_ QYHSL 491_ DVIGF 496_ LLAVV 501_ LTVAF 506_ ITFKC 511_ CAYGY 516_ RKCLG 521_ KKGRV 526_KKAHK
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23288867, PubMed:23756265, PubMed:24641623, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515)
2: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1