UDP-glucuronosyltransferase 1A5 (UGT1A5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-5) (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E)
1_MATGL 6_ QVPLP 11_ QLATG 16_ LLLLL 21_ SVQPW 26_ AESGK 31_ VLVVP 36_ TDGSH 41_ WLSMR 46_ EALRD 51_ LHARG 56_ HQVVV 61_ LTLEV 66_ NMYIK 71_ EENFF 76_ TLTTY 81_ AISWT 86_ QDEFD 91_ RLLLG 96_ HTQSF 101_ FETEH 106_ LLMKF 111_ SRRMA 116_ IMNNM 121_ SLIIH 126_ RSCVE 131_ LLHNE 136_ ALIRH 141_ LHATS 146_ FDVVL 151_ TDPFH 156_ LCAAV 161_ LAKYL 166_ SIPAV 171_ FFLRN 176_ IPCDL 181_ DFKGT 186_ QCPNP 191_ SSYIP 196_ RLLTT 201_ NSDHM 206_ TFLQR 211_ VKNML 216_ YPLAL 221_ SYLCH 226_ AVSAP 231_ YASLA 236_ SELFQ 241_ REVSV 246_ VDLVS 251_ HASVW 256_ LFRGD 261_ FVMDY 266_ PRPIM 271_ PNMVF 276_ IGGIN 281_ CANGK 286_ PLSQE 291_ FEAYI 296_ NASGE 301_ HGIVV 306_ FSLGS 311_ MVSEI 316_ PEKKA 321_ MAIAD 326_ ALGKI 331_ PQTVL 336_ WRYTG 341_ TRPSN 346_ LANNT 351_ ILVKW 356_ LPQND 361_ LLGHP 366_ MTRAF 371_ ITHAG 376_ SHGVY 381_ ESICN 386_ GVPMV 391_ MMPLF 396_ GDQMD 401_ NAKRM 406_ ETKGA 411_ GVTLN 416_ VLEMT 421_ SEDLE 426_ NALKA 431_ VINDK 436_ SYKEN 441_ IMRLS 446_ SLHKD 451_ RPVEP 456_ LDLAV 461_ FWVEF 466_ VMRHK 471_ GAPHL 476_ RPAAH 481_ DLTWY 486_ QYHSL 491_ DVIGF 496_ LLAVV 501_ LTVAF 506_ ITFKC 511_ CAYGY 516_ RKCLG 521_ KKGRV 526_KKAHK
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18674515). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18674515). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515)
2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1