Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)
1_MPSET 6_ PQAEV 11_ GPTGC 16_ PHRSG 21_ PHSAK 26_ GSLEK 31_ GSPED 36_ KEAKE 41_ PLWIR 46_ PDAPS 51_ RCTWQ 56_ LGRPA 61_ SESPH 66_ HHTAP 71_ AKSPK 76_ ILPDI 81_ LKKIG 86_ DTPMV 91_ RINKI 96_ GKKFG 101_ LKCEL 106_ LAKCE 111_ FFNAG 116_ GSVKD 121_ RISLR 126_ MIEDA 131_ ERDGT 136_ LKPGD 141_ TIIEP 146_ TSGNT 151_ GIGLA 156_ LAAAV 161_ RGYRC 166_ IIVMP 171_ EKMSS 176_ EKVDV 181_ LRALG 186_ AEIVR 191_ TPTNA 196_ RFDSP 201_ ESHVG 206_ VAWRL 211_ KNEIP 216_ NSHIL 221_ DQYRN 226_ ASNPL 231_ AHYDT 236_ TADEI 241_ LQQCD 246_ GKLDM 251_ LVASV 256_ GTGGT 261_ ITGIA 266_ RKLKE 271_ KCPGC 276_ RIIGV 281_ DPEGS 286_ ILAEP 291_ EELNQ 296_ TEQTT 301_ YEVEG 306_ IGYDF 311_ IPTVL 316_ DRTVV 321_ DKWFK 326_ SNDEE 331_ AFTFA 336_ RMLIA 341_ QEGLL 346_ CGGSA 351_ GSTVA 356_ VAVKA 361_ AQELQ 366_ EGQRC 371_ VVILP 376_ DSVRN 381_ YMTKF 386_ LSDRW 391_ MLQKG 396_ FLKEE 401_ DLTEK 406_ KPWWW 411_ HLRVQ 416_ ELGLS 421_ APLTV 426_ LPTIT 431_ CGHTI 436_ EILRE 441_ KGFDQ 446_ APVVD 451_ EAGVI 456_ LGMVT 461_ LGNML 466_ SSLLA 471_ GKVQP 476_ SDQVG 481_ KVIYK 486_ QFKQI 491_ RLTDT 496_ LGRLS 501_ HILEM 506_ DHFAL 511_ VVHEQ 516_ IQYHS 521_ TGKSS 526_ QRQMV 531_ FGVVT 536_ AIDLL 541_ NFVAA 546_QERDQ
1: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity)