Homeobox protein MSX-2 (Homeobox protein Hox-8)
1_MASPS 6_ KGNDL 11_ FSPDE 16_ EGPAV 21_ VAGPG 26_ PGPGG 31_ AEGAA 36_ EERRV 41_ KVSSL 46_ PFSVE 51_ ALMSD 56_ KKPPK 61_ EASPL 66_ PAESA 71_ SAGAT 76_ LRPLL 81_ LSGHG 86_ AREAH 91_ SPGPL 96_ VKPFE 101_ TASVK 106_ SENSE 111_ DGAAW 116_ MQEPG 121_ RYSPP 126_ PRHMS 131_ PTTCT 136_ LRKHK 141_ TNRKP 146_ RTPFT 151_ TSQLL 156_ ALERK 161_ FRQKQ 166_ YLSIA 171_ ERAEF 176_ SSSLN 181_ LTETQ 186_ VKIWF 191_ QNRRA 196_ KAKRL 201_ QEAEL 206_ EKLKM 211_ AAKPM 216_ LPSSF 221_ SLPFP 226_ ISSPL 231_ QAASI 236_ YGASY 241_ PFHRP 246_ VLPIP 251_ PVGLY 256_ ATPVG 261_YGMYH
1: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter