Fibrillin-1 [Cleaved into: Asprosin]
1_MRRGR 6_ LLEIA 11_ LGFTV 16_ LLASY 21_ TSHGA 26_ DANLE 31_ AGNVK 36_ ETRAS 41_ RAKRR 46_ GGGGH 51_ DALKG 56_ PNVCG 61_ SRYNA 66_ YCCPG 71_ WKTLP 76_ GGNQC 81_ IVPIC 86_ RHSCG 91_ DGFCS 96_ RPNMC 101_ TCPSG 106_ QIAPS 111_ CGSRS 116_ IQHCN 121_ IRCMN 126_ GGSCS 131_ DDHCL 136_ CQKGY 141_ IGTHC 146_ GQPVC 151_ ESGCL 156_ NGGRC 161_ VAPNR 166_ CACTY 171_ GFTGP 176_ QCERD 181_ YRTGP 186_ CFTVI 191_ SNQMC 196_ QGQLS 201_ GIVCT 206_ KTLCC 211_ ATVGR 216_ AWGHP 221_ CEMCP 226_ AQPHP 231_ CRRGF 236_ IPNIR 241_ TGACQ 246_ DVDEC 251_ QAIPG 256_ LCQGG 261_ NCINT 266_ VGSFE 271_ CKCPA 276_ GHKLN 281_ EVSQK 286_ CEDID 291_ ECSTI 296_ PGICE 301_ GGECT 306_ NTVSS 311_ YFCKC 316_ PPGFY 321_ TSPDG 326_ TRCID 331_ VRPGY 336_ CYTAL 341_ TNGRC 346_ SNQLP 351_ QSITK 356_ MQCCC 361_ DAGRC 366_ WSPGV 371_ TVAPE 376_ MCPIR 381_ ATEDF 386_ NKLCS 391_ VPMVI 396_ PGRPE 401_ YPPPP 406_ LGPIP 411_ PVLPV 416_ PPGFP 421_ PGPQI 426_ PVPRP 431_ PVEYL 436_ YPSRE 441_ PPRVL 446_ PVNVT 451_ DYCQL 456_ VRYLC 461_ QNGRC 466_ IPTPG 471_ SYRCE 476_ CNKGF 481_ QLDLR 486_ GECID 491_ VDECE 496_ KNPCA 501_ GGECI 506_ NNQGS 511_ YTCQC 516_ RAGYQ 521_ STLTR 526_ TECRD 531_ IDECL 536_ QNGRI 541_ CNNGR 546_ CINTD 551_ GSFHC 556_ VCNAG 561_ FHVTR 566_ DGKNC 571_ EDMDE 576_ CSIRN 581_ MCLNG 586_ MCINE 591_ DGSFK 596_ CICKP 601_ GFQLA 606_ SDGRY 611_ CKDIN 616_ ECETP 621_ GICMN 626_ GRCVN 631_ TDGSY 636_ RCECF 641_ PGLAV 646_ GLDGR 651_ VCVDT 656_ HMRST 661_ CYGGY 666_ KRGQC 671_ IKPLF 676_ GAVTK 681_ SECCC 686_ ASTEY 691_ AFGEP 696_ CQPCP 701_ AQNSA 706_ EYQAL 711_ CSSGP 716_ GMTSA 721_ GSDIN 726_ ECALD 731_ PDICP 736_ NGICE 741_ NLRGT 746_ YKCIC 751_ NSGYE 756_ VDSTG 761_ KNCVD 766_ INECV 771_ LNSLL 776_ CDNGQ 781_ CRNTP 786_ GSFVC 791_ TCPKG 796_ FIYKP 801_ DLKTC 806_ EDIDE 811_ CESSP 816_ CINGV 821_ CKNSP 826_ GSFIC 831_ ECSSE 836_ STLDP 841_ TKTIC 846_ IETIK 851_ GTCWQ 856_ TVIDG 861_ RCEIN 866_ INGAT 871_ LKSQC 876_ CSSLG 881_ AAWGS 886_ PCTLC 891_ QVDPI 896_ CGKGY 901_ SRIKG 906_ TQCED 911_ IDECE 916_ VFPGV 921_ CKNGL 926_ CVNTR 931_ GSFKC 936_ QCPSG 941_ MTLDA 946_ TGRIC 951_ LDIRL 956_ ETCFL 961_ RYEDE 966_ ECTLP 971_ IAGRH 976_ RMDAC 981_ CCSVG 986_ AAWGT 991_ EECEE 996_ CPMRN 1001_ TPEYE 1006_ ELCPR 1011_ GPGFA 1016_ TKEIT 1021_ NGKPF 1026_ FKDIN 1031_ ECKMI 1036_ PSLCT 1041_ HGKCR 1046_ NTIGS 1051_ FKCRC 1056_ DSGFA 1061_ LDSEE 1066_ RNCTD 1071_ IDECR 1076_ ISPDL 1081_ CGRGQ 1086_ CVNTP 1091_ GDFEC 1096_ KCDEG 1101_ YESGF 1106_ MMMKN 1111_ CMDID 1116_ ECQRD 1121_ PLLCR 1126_ GGVCH 1131_ NTEGS 1136_ YRCEC 1141_ PPGHQ 1146_ LSPNI 1151_ SACID 1156_ INECE 1161_ LSAHL 1166_ CPNGR 1171_ CVNLI 1176_ GKYQC 1181_ ACNPG 1186_ YHSTP 1191_ DRLFC 1196_ VDIDE 1201_ CSIMN 1206_ GGCET 1211_ FCTNS 1216_ EGSYE 1221_ CSCQP 1226_ GFALM 1231_ PDQRS 1236_ CTDID 1241_ ECEDN 1246_ PNICD 1251_ GGQCT 1256_ NIPGE 1261_ YRCLC 1266_ YDGFM 1271_ ASEDM 1276_ KTCVD 1281_ VNECD 1286_ LNPNI 1291_ CLSGT 1296_ CENTK 1301_ GSFIC 1306_ HCDMG 1311_ YSGKK 1316_ GKTGC 1321_ TDINE 1326_ CEIGA 1331_ HNCGK 1336_ HAVCT 1341_ NTAGS 1346_ FKCSC 1351_ SPGWI 1356_ GDGIK 1361_ CTDLD 1366_ ECSNG 1371_ THMCS 1376_ QHADC 1381_ KNTMG 1386_ SYRCL 1391_ CKEGY 1396_ TGDGF 1401_ TCTDL 1406_ DECSE 1411_ NLNLC 1416_ GNGQC 1421_ LNAPG 1426_ GYRCE 1431_ CDMGF 1436_ VPSAD 1441_ GKACE 1446_ DIDEC 1451_ SLPNI 1456_ CVFGT 1461_ CHNLP 1466_ GLFRC 1471_ ECEIG 1476_ YELDR 1481_ SGGNC 1486_ TDVNE 1491_ CLDPT 1496_ TCISG 1501_ NCVNT 1506_ PGSYI 1511_ CDCPP 1516_ DFELN 1521_ PTRVG 1526_ CVDTR 1531_ SGNCY 1536_ LDIRP 1541_ RGDNG 1546_ DTACS 1551_ NEIGV 1556_ GVSKA 1561_ SCCCS 1566_ LGKAW 1571_ GTPCE 1576_ MCPAV 1581_ NTSEY 1586_ KILCP 1591_ GGEGF 1596_ RPNPI 1601_ TVILE 1606_ DIDEC 1611_ QELPG 1616_ LCQGG 1621_ KCINT 1626_ FGSFQ 1631_ CRCPT 1636_ GYYLN 1641_ EDTRV 1646_ CDDVN 1651_ ECETP 1656_ GICGP 1661_ GTCYN 1666_ TVGNY 1671_ TCICP 1676_ PDYMQ 1681_ VNGGN 1686_ NCMDM 1691_ RRSLC 1696_ YRNYY 1701_ ADNQT 1706_ CDGEL 1711_ LFNMT 1716_ KKMCC 1721_ CSYNI 1726_ GRAWN 1731_ KPCEQ 1736_ CPIPS 1741_ TDEFA 1746_ TLCGS 1751_ QRPGF 1756_ VIDIY 1761_ TGLPV 1766_ DIDEC 1771_ REIPG 1776_ VCENG 1781_ VCINM 1786_ VGSFR 1791_ CECPV 1796_ GFFYN 1801_ DKLLV 1806_ CEDID 1811_ ECQNG 1816_ PVCQR 1821_ NAECI 1826_ NTAGS 1831_ YRCDC 1836_ KPGYR 1841_ FTSTG 1846_ QCNDR 1851_ NECQE 1856_ IPNIC 1861_ SHGQC 1866_ IDTVG 1871_ SFYCL 1876_ CHTGF 1881_ KTNDD 1886_ QTMCL 1891_ DINEC 1896_ ERDAC 1901_ GNGTC 1906_ RNTIG 1911_ SFNCR 1916_ CNHGF 1921_ ILSHN 1926_ NDCID 1931_ VDECA 1936_ SGNGN 1941_ LCRNG 1946_ QCINT 1951_ VGSFQ 1956_ CQCNE 1961_ GYEVA 1966_ PDGRT 1971_ CVDIN 1976_ ECLLE 1981_ PRKCA 1986_ PGTCQ 1991_ NLDGS 1996_ YRCIC 2001_ PPGYS 2006_ LQNEK 2011_ CEDID 2016_ ECVEE 2021_ PEICA 2026_ LGTCS 2031_ NTEGS 2036_ FKCLC 2041_ PEGFS 2046_ LSSSG 2051_ RRCQD 2056_ LRMSY 2061_ CYAKF 2066_ EGGKC 2071_ SSPKS 2076_ RNHSK 2081_ QECCC 2086_ ALKGE 2091_ GWGDP 2096_ CELCP 2101_ TEPDE 2106_ AFRQI 2111_ CPYGS 2116_ GIIVG 2121_ PDDSA 2126_ VDMDE 2131_ CKEPD 2136_ VCKHG 2141_ QCINT 2146_ DGSYR 2151_ CECPF 2156_ GYILA 2161_ GNECV 2166_ DTDEC 2171_ SVGNP 2176_ CGNGT 2181_ CKNVI 2186_ GGFEC 2191_ TCEEG 2196_ FEPGP 2201_ MMTCE 2206_ DINEC 2211_ AQNPL 2216_ LCAFR 2221_ CVNTY 2226_ GSYEC 2231_ KCPVG 2236_ YVLRE 2241_ DRRMC 2246_ KDEDE 2251_ CEEGK 2256_ HDCTE 2261_ KQMEC 2266_ KNLIG 2271_ TYMCI 2276_ CGPGY 2281_ QRRPD 2286_ GEGCV 2291_ DENEC 2296_ QTKPG 2301_ ICENG 2306_ RCLNT 2311_ RGSYT 2316_ CECND 2321_ GFTAS 2326_ PNQDE 2331_ CLDNR 2336_ EGYCF 2341_ TEVLQ 2346_ NMCQI 2351_ GSSNR 2356_ NPVTK 2361_ SECCC 2366_ DGGRG 2371_ WGPHC 2376_ EICPF 2381_ QGTVA 2386_ FKKLC 2391_ PHGRG 2396_ FMTNG 2401_ ADIDE 2406_ CKVIH 2411_ DVCRN 2416_ GECVN 2421_ DRGSY 2426_ HCICK 2431_ TGYTP 2436_ DITGT 2441_ SCVDL 2446_ NECNQ 2451_ APKPC 2456_ NFICK 2461_ NTEGS 2466_ YQCSC 2471_ PKGYI 2476_ LQEDG 2481_ RSCKD 2486_ LDECA 2491_ TKQHN 2496_ CQFLC 2501_ VNTIG 2506_ GFTCK 2511_ CPPGF 2516_ TQHHT 2521_ SCIDN 2526_ NECTS 2531_ DINLC 2536_ GSKGI 2541_ CQNTP 2546_ GSFTC 2551_ ECQRG 2556_ FSLDQ 2561_ TGSSC 2566_ EDVDE 2571_ CEGNH 2576_ RCQHG 2581_ CQNII 2586_ GGYRC 2591_ SCPQG 2596_ YLQHY 2601_ QWNQC 2606_ VDENE 2611_ CLSAH 2616_ ICGGA 2621_ SCHNT 2626_ LGSYK 2631_ CMCPA 2636_ GFQYE 2641_ QFSGG 2646_ CQDIN 2651_ ECGSA 2656_ QAPCS 2661_ YGCSN 2666_ TEGGY 2671_ LCGCP 2676_ PGYFR 2681_ IGQGH 2686_ CVSGM 2691_ GMGRG 2696_ NPEPP 2701_ VSGEM 2706_ DDNSL 2711_ SPEAC 2716_ YECKI 2721_ NGYPK 2726_ RGRKR 2731_ RSTNE 2736_ TDASN 2741_ IEDQS 2746_ ETEAN 2751_ VSLAS 2756_ WDVEK 2761_ TAIFA 2766_ FNISH 2771_ VSNKV 2776_ RILEL 2781_ LPALT 2786_ TLTNH 2791_ NRYLI 2796_ ESGNE 2801_ DGFFK 2806_ INQKE 2811_ GISYL 2816_ HFTKK 2821_ KPVAG 2826_ TYSLQ 2831_ ISSTP 2836_ LYKKK 2841_ ELNQL 2846_ EDKYD 2851_ KDYLS 2856_ GELGD 2861_ NLKMK 2866_IQVLL
1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:15062093, PubMed:1860873). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921)
2: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity)