Insulin receptor substrate 1 (IRS-1)
1_MASPP 6_ ESDGF 11_ SDVRK 16_ VGYLR 21_ KPKSM 26_ HKRFF 31_ VLRAA 36_ SEAGG 41_ PARLE 46_ YYENE 51_ KKWRH 56_ KSSAP 61_ KRSIP 66_ LESCF 71_ NINKR 76_ ADSKN 81_ KHLVA 86_ LYTRD 91_ EHFAI 96_ AADSE 101_ AEQDS 106_ WYQAL 111_ LQLHN 116_ RAKGH 121_ HDGAA 126_ ALGAG 131_ GGGGS 136_ CSGSS 141_ GLGEA 146_ GEDLS 151_ YGDVP 156_ PGPAF 161_ KEVWQ 166_ VILKP 171_ KGLGQ 176_ TKNLI 181_ GIYRL 186_ CLTSK 191_ TISFV 196_ KLNSE 201_ AAAVV 206_ LQLMN 211_ IRRCG 216_ HSENF 221_ FFIEV 226_ GRSAV 231_ TGPGE 236_ FWMQV 241_ DDSVV 246_ AQNMH 251_ ETILE 256_ AMRAM 261_ SDEFR 266_ PRSKS 271_ QSSSN 276_ CSNPI 281_ SVPLR 286_ RHHLN 291_ NPPPS 296_ QVGLT 301_ RRSRT 306_ ESITA 311_ TSPAS 316_ MVGGK 321_ PGSFR 326_ VRASS 331_ DGEGT 336_ MSRPA 341_ SVDGS 346_ PVSPS 351_ TNRTH 356_ AHRHR 361_ GSARL 366_ HPPLN 371_ HSRSI 376_ PMPAS 381_ RCSPS 386_ ATSPV 391_ SLSSS 396_ STSGH 401_ GSTSD 406_ CLFPR 411_ RSSAS 416_ VSGSP 421_ SDGGF 426_ ISSDE 431_ YGSSP 436_ CDFRS 441_ SFRSV 446_ TPDSL 451_ GHTPP 456_ ARGEE 461_ ELSNY 466_ ICMGG 471_ KGPST 476_ LTAPN 481_ GHYIL 486_ SRGGN 491_ GHRCT 496_ PGTGL 501_ GTSPA 506_ LAGDE 511_ AASAA 516_ DLDNR 521_ FRKRT 526_ HSAGT 531_ SPTIT 536_ HQKTP 541_ SQSSV 546_ ASIEE 551_ YTEMM 556_ PAYPP 561_ GGGSG 566_ GRLPG 571_ HRHSA 576_ FVPTR 581_ SYPEE 586_ GLEMH 591_ PLERR 596_ GGHHR 601_ PDSST 606_ LHTDD 611_ GYMPM 616_ SPGVA 621_ PVPSG 626_ RKGSG 631_ DYMPM 636_ SPKSV 641_ SAPQQ 646_ IINPI 651_ RRHPQ 656_ RVDPN 661_ GYMMM 666_ SPSGG 671_ CSPDI 676_ GGGPS 681_ SSSSS 686_ SNAVP 691_ SGTSY 696_ GKLWT 701_ NGVGG 706_ HHSHV 711_ LPHPK 716_ PPVES 721_ SGGKL 726_ LPCTG 731_ DYMNM 736_ SPVGD 741_ SNTSS 746_ PSDCY 751_ YGPED 756_ PQHKP 761_ VLSYY 766_ SLPRS 771_ FKHTQ 776_ RPGEP 781_ EEGAR 786_ HQHLR 791_ LSTSS 796_ GRLLY 801_ AATAD 806_ DSSSS 811_ TSSDS 816_ LGGGY 821_ CGARL 826_ EPSLP 831_ HPHHQ 836_ VLQPH 841_ LPRKV 846_ DTAAQ 851_ TNSRL 856_ ARPTR 861_ LSLGD 866_ PKAST 871_ LPRAR 876_ EQQQQ 881_ QQPLL 886_ HPPEP 891_ KSPGE 896_ YVNIE 901_ FGSDQ 906_ SGYLS 911_ GPVAF 916_ HSSPS 921_ VRCPS 926_ QLQPA 931_ PREEE 936_ TGTEE 941_ YMKMD 946_ LGPGR 951_ RAAWQ 956_ ESTGV 961_ EMGRL 966_ GPAPP 971_ GAASI 976_ CRPTR 981_ AVPSS 986_ RGDYM 991_ TMQMS 996_ CPRQS 1001_ YVDTS 1006_ PAAPV 1011_ SYADM 1016_ RTGIA 1021_ AEEVS 1026_ LPRAT 1031_ MAAAS 1036_ SSSAA 1041_ SASPT 1046_ GPQGA 1051_ AELAA 1056_ HSSLL 1061_ GGPQG 1066_ PGGMS 1071_ AFTRV 1076_ NLSPN 1081_ RNQSA 1086_ KVIRA 1091_ DPQGC 1096_ RRRHS 1101_ SETFS 1106_ STPSA 1111_ TRVGN 1116_ TVPFG 1121_ AGAAV 1126_ GGGGG 1131_ SSSSS 1136_ EDVKR 1141_ HSSAS 1146_ FENVW 1151_ LRPGE 1156_ LGGAP 1161_ KEPAK 1166_ LCGAA 1171_ GGLEN 1176_ GLNYI 1181_ DLDLV 1186_ KDFKQ 1191_ CPQEC 1196_ TPEPQ 1201_ PPPPP 1206_ PPHQP 1211_ LGSGE 1216_ SSSTR 1221_ RSSED 1226_ LSAYA 1231_ SISFQ 1236_KQPED
1: Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100)