Glucose-6-phosphatase catalytic subunit 1 (EC 3.1.3.9) (Glucose-6-phosphatase) (G-6-Pase) (G6Pase) (Glucose-6-phosphatase alpha) (G6Pase-alpha)
1_MEEGM 6_ NVLHD 11_ FGIQS 16_ THYLQ 21_ VNYQD 26_ SQDWF 31_ ILVSV 36_ IADLR 41_ NAFYV 46_ LFPIW 51_ FHLQE 56_ AVGIK 61_ LLWVA 66_ VIGDW 71_ LNLVF 76_ KWILF 81_ GQRPY 86_ WWVLD 91_ TDYYS 96_ NTSVP 101_ LIKQF 106_ PVTCE 111_ TGPGS 116_ PSGHA 121_ MGTAG 126_ VYYVM 131_ VTSTL 136_ SIFQG 141_ KIKPT 146_ YRFRC 151_ LNVIL 156_ WLGFW 161_ AVQLN 166_ VCLSR 171_ IYLAA 176_ HFPHQ 181_ VVAGV 186_ LSGIA 191_ VAETF 196_ SHIHS 201_ IYNAS 206_ LKKYF 211_ LITFF 216_ LFSFA 221_ IGFYL 226_ LLKGL 231_ GVDLL 236_ WTLEK 241_ AQRWC 246_ EQPEW 251_ VHIDT 256_ TPFAS 261_ LLKNL 266_ GTLFG 271_ LGLAL 276_ NSSMY 281_ RESCK 286_ GKLSK 291_ WLPFR 296_ LSSIV 301_ ASLVL 306_ LHVFD 311_ SLKPP 316_ SQVEL 321_ VFYVL 326_ SFCKS 331_ AVVPL 336_ ASVSV 341_ IPYCL 346_ AQVLG 351_QPHKK
1: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels