Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
1_MVGEE 6_ KMSLR 11_ NRLSK 16_ SRENP 21_ EEDED 26_ QRNPA 31_ KESLE 36_ TPSNG 41_ RIDIK 46_ QLIAK 51_ KIKLT 56_ AEAEE 61_ LKPFF 66_ MKEVG 71_ SHFDD 76_ FVTNL 81_ IEKSA 86_ SLDNG 91_ GCALT 96_ TFSVL 101_ EGEKN 106_ NHRAK 111_ DLRAP 116_ PEQGK 121_ IFIAR 126_ RSLLD 131_ ELLEV 136_ DHIRT 141_ IYHMF 146_ IALLI 151_ LFILS 156_ TLVVD 161_ YIDEG 166_ RLVLE 171_ FSLLS 176_ YAFGK 181_ FPTVV 186_ WTWWI 191_ MFLST 196_ FSVPY 201_ FLFQH 206_ WATGY 211_ SKSSH 216_ PLIRS 221_ LFHGF 226_ LFMIF 231_ QIGVL 236_ GFGPT 241_ YVVLA 246_ YTLPP 251_ ASRFI 256_ IIFEQ 261_ IRFVM 266_ KAHSF 271_ VRENV 276_ PRVLN 281_ SAKEK 286_ SSTVP 291_ IPTVN 296_ QYLYF 301_ LFAPT 306_ LIYRD 311_ SYPRN 316_ PTVRW 321_ GYVAM 326_ KFAQV 331_ FGCFF 336_ YVYYI 341_ FERLC 346_ APLFR 351_ NIKQE 356_ PFSAR 361_ VLVLC 366_ VFNSI 371_ LPGVL 376_ ILFLT 381_ FFAFL 386_ HCWLN 391_ AFAEM 396_ LRFGD 401_ RMFYK 406_ DWWNS 411_ TSYSN 416_ YYRTW 421_ NVVVH 426_ DWLYY 431_ YAYKD 436_ FLWFF 441_ SKRFK 446_ SAAML 451_ AVFAV 456_ SAVVH 461_ EYALA 466_ VCLSF 471_ FYPVL 476_ FVLFM 481_ FFGMA 486_ FNFIV 491_ NDSRK 496_ KPIWN 501_ VLMWT 506_ SLFLG 511_ NGVLL 516_ CFYSQ 521_ EWYAR 526_ QHCPL 531_ KNPTF 536_ LDYVR 541_PRSWT
1: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614)