Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)
1_MAAAL 6_ FVLLG 11_ FALLG 16_ THGAS 21_ GAAGF 26_ VQAPL 31_ SQQRW 36_ VGGSV 41_ ELHCE 46_ AVGSP 51_ VPEIQ 56_ WWFEG 61_ QGPND 66_ TCSQL 71_ WDGAR 76_ LDRVH 81_ IHATY 86_ HQHAA 91_ STISI 96_ DTLVE 101_ EDTGT 106_ YECRA 111_ SNDPD 116_ RNHLT 121_ RAPRV 126_ KWVRA 131_ QAVVL 136_ VLEPG 141_ TVFTT 146_ VEDLG 151_ SKILL 156_ TCSLN 161_ DSATE 166_ VTGHR 171_ WLKGG 176_ VVLKE 181_ DALPG 186_ QKTEF 191_ KVDSD 196_ DQWGE 201_ YSCVF 206_ LPEPM 211_ GTANI 216_ QLHGP 221_ PRVKA 226_ VKSSE 231_ HINEG 236_ ETAML 241_ VCKSE 246_ SVPPV 251_ TDWAW 256_ YKITD 261_ SEDKA 266_ LMNGS 271_ ESRFF 276_ VSSSQ 281_ GRSEL 286_ HIENL 291_ NMEAD 296_ PGQYR 301_ CNGTS 306_ SKGSD 311_ QAIIT 316_ LRVRS 321_ HLAAL 326_ WPFLG 331_ IVAEV 336_ LVLVT 341_ IIFIY 346_ EKRRK 351_ PEDVL 356_ DDDDA 361_ GSAPL 366_ KSSGQ 371_ HQNDK 376_GKNVR
1: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857)
2: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2
3: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850)
4: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866)
5: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA
6: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA
7: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection
8: (Microbial infection) Acts as a receptor for measles virus
9: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells