RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
1_MASND 6_ YTQQA 11_ TQSYG 16_ AYPTQ 21_ PGQGY 26_ SQQSS 31_ QPYGQ 36_ QSYSG 41_ YSQST 46_ DTSGY 51_ GQSSY 56_ SSYGQ 61_ SQNTG 66_ YGTQS 71_ TPQGY 76_ GSTGG 81_ YGSSQ 86_ SSQSS 91_ YGQQS 96_ SYPGY 101_ GQQPA 106_ PSSTS 111_ GSYGS 116_ SSQSS 121_ SYGQP 126_ QSGSY 131_ SQQPS 136_ YGGQQ 141_ QSYGQ 146_ QQSYN 151_ PPQGY 156_ GQQNQ 161_ YNSSS 166_ GGGGG 171_ GGGGG 176_ NYGQD 181_ QSSMS 186_ SGGGS 191_ GGGYG 196_ NQDQS 201_ GGGGS 206_ GGYGQ 211_ QDRGG 216_ RGRGG 221_ SGGGG 226_ GGGGG 231_ GYNRS 236_ SGGYE 241_ PRGRG 246_ GGRGG 251_ RGGMG 256_ GSDRG 261_ GFNKF 266_ GGPRD 271_ QGSRH 276_ DSEQD 281_ NSDNN 286_ TIFVQ 291_ GLGEN 296_ VTIES 301_ VADYF 306_ KQIGI 311_ IKTNK 316_ KTGQP 321_ MINLY 326_ TDRET 331_ GKLKG 336_ EATVS 341_ FDDPP 346_ SAKAA 351_ IDWFD 356_ GKEFS 361_ GNPIK 366_ VSFAT 371_ RRADF 376_ NRGGG 381_ NGRGG 386_ RGRGG 391_ PMGRG 396_ GYGGG 401_ GSGGG 406_ GRGGF 411_ PSGGG 416_ GGGGQ 421_ QRAGD 426_ WKCPN 431_ PTCEN 436_ MNFSW 441_ RNECN 446_ QCKAP 451_ KPDGP 456_ GGGPG 461_ GSHMG 466_ GNYGD 471_ DRRGG 476_ RGGYD 481_ RGGYR 486_ GRGGD 491_ RGGFR 496_ GGRGG 501_ GDRGG 506_ FGPGK 511_ MDSRG 516_ EHRQD 521_RRERP
1: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity)