Transcription factor SOX-5
1_MLTDP 6_ DLPQE 11_ FERMS 16_ SKRPA 21_ SPYGE 26_ ADGEV 31_ AMVTS 36_ RQKVE 41_ EEESD 46_ GLPAF 51_ HLPLH 56_ VSFPN 61_ KPHSE 66_ EFQPV 71_ SLLTQ 76_ ETCGH 81_ RTPTS 86_ QHNTM 91_ EVDGN 96_ KVMSS 101_ FAPHN 106_ SSTSP 111_ QKAEE 116_ GGRQS 121_ GESLS 126_ STALG 131_ TPERR 136_ KGSLA 141_ DVVDT 146_ LKQRK 151_ MEELI 156_ KNEPE 161_ ETPSI 166_ EKLLS 171_ KDWKD 176_ KLLAM 181_ GSGNF 186_ GEIKG 191_ TPESL 196_ AEKER 201_ QLMGM 206_ INQLT 211_ SLREQ 216_ LLAAH 221_ DEQKK 226_ LAASQ 231_ IEKQR 236_ QQMEL 241_ AKQQQ 246_ EQIAR 251_ QQQQL 256_ LQQQH 261_ KINLL 266_ QQQIQ 271_ VQGQL 276_ PPLMI 281_ PVFPP 286_ DQRTL 291_ AAAAQ 296_ QGFLL 301_ PPGFS 306_ YKAGC 311_ SDPYP 316_ VQLIP 321_ TTMAA 326_ AAAAT 331_ PGLGP 336_ LQLQQ 341_ LYAAQ 346_ LAAMQ 351_ VSPGG 356_ KLPGI 361_ PQGNL 366_ GAAVS 371_ PTSIH 376_ TDKST 381_ NSPPP 386_ KSKDE 391_ VAQPL 396_ NLSAK 401_ PKTSD 406_ GKSPT 411_ SPTSP 416_ HMPAL 421_ RINSG 426_ AGPLK 431_ ASVPA 436_ ALASP 441_ SARVS 446_ TIGYL 451_ NDHDA 456_ VTKAI 461_ QEARQ 466_ MKEQL 471_ RREQQ 476_ VLDGK 481_ VAVVN 486_ SLGLN 491_ NCRTE 496_ KEKTT 501_ LESLT 506_ QQLAV 511_ KQNEE 516_ GKFSH 521_ AMMDF 526_ NLSGD 531_ SDGSA 536_ GVSES 541_ RIYRE 546_ SRGRG 551_ SNEPH 556_ IKRPM 561_ NAFMV 566_ WAKDE 571_ RRKIL 576_ QAFPD 581_ MHNSN 586_ ISKIL 591_ GSRWK 596_ AMTNL 601_ EKQPY 606_ YEEQA 611_ RLSKQ 616_ HLEKY 621_ PDYKY 626_ KPRPK 631_ RTCLV 636_ DGKKL 641_ RIGEY 646_ KAIMR 651_ NRRQE 656_ MRQYF 661_ NVGQQ 666_ AQIPI 671_ ATAGV 676_ VYPGA 681_ IAMAG 686_ MPSPH 691_ LPSEH 696_ SSVSS 701_ SPEPG 706_ MPVIQ 711_ STYGV 716_ KGEEP 721_ HIKEE 726_ IQAED 731_ INGEI 736_ YDEYD 741_ EEEDD 746_ PDVDY 751_ GSDSE 756_NHIAG
1: Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene