Transcription factor SOX-6
1_MSSKQ 6_ ATSPF 11_ ACAAD 16_ GEDAM 21_ TQDLT 26_ SREKE 31_ EGSDQ 36_ HVASH 41_ LPLHP 46_ IMHNK 51_ PHSEE 56_ LPTLV 61_ STIQQ 66_ DADWD 71_ SVLSS 76_ QQRME 81_ SENNK 86_ LCSLY 91_ SFRNT 96_ STSPH 101_ KPDEG 106_ SRDRE 111_ IMTSV 116_ TFGTP 121_ ERRKG 126_ SLADV 131_ VDTLK 136_ QKKLE 141_ EMTRT 146_ EQEDS 151_ SCMEK 156_ LLSKD 161_ WKEKM 166_ ERLNT 171_ SELLG 176_ EIKGT 181_ PESLA 186_ EKERQ 191_ LSTMI 196_ TQLIS 201_ LREQL 206_ LAAHD 211_ EQKKL 216_ AASQI 221_ EKQRQ 226_ QMDLA 231_ RQQQE 236_ QIARQ 241_ QQQLL 246_ QQQHK 251_ INLLQ 256_ QQIQV 261_ QGHMP 266_ PLMIP 271_ IFPHD 276_ QRTLA 281_ AAAAA 286_ QQGFL 291_ FPPGI 296_ TYKPG 301_ DNYPV 306_ QFIPS 311_ TMAAA 316_ AASGL 321_ SPLQL 326_ QKGHV 331_ SHPQI 336_ NQRLK 341_ GLSDR 346_ FGRNL 351_ DTFEH 356_ GGGHS 361_ YNHKQ 366_ IEQLY 371_ AAQLA 376_ SMQVS 381_ PGAKM 386_ PSTPQ 391_ PPNTA 396_ GTVSP 401_ TGIKN 406_ EKRGT 411_ SPVTQ 416_ VKDEA 421_ AAQPL 426_ NLSSR 431_ PKTAE 436_ PVKSP 441_ TSPTQ 446_ NLFPA 451_ SKTSP 456_ VNLPN 461_ KSSIP 466_ SPIGG 471_ SLGRG 476_ SSLDI 481_ LSSLN 486_ SPALF 491_ GDQDT 496_ VMKAI 501_ QEARK 506_ MREQI 511_ QREQQ 516_ QQQPH 521_ GVDGK 526_ LSSIN 531_ NMGLN 536_ SCRNE 541_ KERTR 546_ FENLG 551_ PQLTG 556_ KSNED 561_ GKLGP 566_ GVIDL 571_ TRPED 576_ AEGSK 581_ AMNGS 586_ AAKLQ 591_ QYYCW 596_ PTGGA 601_ TVAEA 606_ RVYRD 611_ ARGRA 616_ SSEPH 621_ IKRPM 626_ NAFMV 631_ WAKDE 636_ RRKIL 641_ QAFPD 646_ MHNSN 651_ ISKIL 656_ GSRWK 661_ SMSNQ 666_ EKQPY 671_ YEEQA 676_ RLSKI 681_ HLEKY 686_ PNYKY 691_ KPRPK 696_ RTCIV 701_ DGKKL 706_ RIGEY 711_ KQLMR 716_ SRRQE 721_ MRQFF 726_ TVGQQ 731_ PQIPI 736_ TTGTG 741_ VVYPG 746_ AITMA 751_ TTTPS 756_ PQMTS 761_ DCSST 766_ SASPE 771_ PSLPV 776_ IQSTY 781_ GMKTD 786_ GGSLA 791_ GNEMI 796_ NGEDE 801_ MEMYD 806_ DYEDD 811_ PKSDY 816_ SSENE 821_APEAV
1: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity)