Transcription factor SOX-18
1_MQRSP 6_ PGYGA 11_ QDDPP 16_ ARRDC 21_ AWAPG 26_ HGAAA 31_ DTRGL 36_ AAGPA 41_ ALAAP 46_ AAPAS 51_ PPSPQ 56_ RSPPR 61_ SPEPG 66_ RYGLS 71_ PAGRG 76_ ERQAA 81_ DESRI 86_ RRPMN 91_ AFMVW 96_ AKDER 101_ KRLAQ 106_ QNPDL 111_ HNAVL 116_ SKMLG 121_ KAWKE 126_ LNAAE 131_ KRPFV 136_ EEAER 141_ LRVQH 146_ LRDHP 151_ NYKYR 156_ PRRKK 161_ QARKA 166_ RRLEP 171_ GLLLP 176_ GLAPP 181_ QPPPE 186_ PFPAA 191_ SGSAR 196_ AFREL 201_ PPLGA 206_ EFDGL 211_ GLPTP 216_ ERSPL 221_ DGLEP 226_ GEAAF 231_ FPPPA 236_ APEDC 241_ ALRPF 246_ RAPYA 251_ PTELS 256_ RDPGG 261_ CYGAP 266_ LAEAL 271_ RTAPP 276_ AAPLA 281_ GLYYG 286_ TLGTP 291_ GPYPG 296_ PLSPP 301_ PEAPP 306_ LESAE 311_ PLGPA 316_ ADLWA 321_ DVDLT 326_ EFDQY 331_ LNCSR 336_ TRPDA 341_ PGLPY 346_ HVALA 351_ KLGPR 356_ AMSCP 361_ EESSL 366_ ISALS 371_ DASSA 376_VYYSA
1: Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development