Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34)
1_MGPLQ 6_ FRDVA 11_ IEFSL 16_ EEWHC 21_ LDTAQ 26_ RNLYR 31_ NVMLE 36_ NYSNL 41_ VFLGI 46_ VVSKP 51_ DLIAH 56_ LEQGK 61_ KPLTM 66_ KRHEM 71_ VANPS 76_ VICSH 81_ FAQDL 86_ WPEQN 91_ IKDSF 96_ QKVIL 101_ RRYEK 106_ RGHGN 111_ LQLIK 116_ RCESV 121_ DECKV 126_ HTGGY 131_ NGLNQ 136_ CSTTT 141_ QSKVF 146_ QCDKY 151_ GKVFH 156_ KFSNS 161_ NRHNI 166_ RHTEK 171_ KPFKC 176_ IECGK 181_ AFNQF 186_ STLIT 191_ HKKIH 196_ TGEKP 201_ YICEE 206_ CGKAF 211_ KYSSA 216_ LNTHK 221_ RIHTG 226_ EKPYK 231_ CDKCD 236_ KAFIA 241_ SSTLS 246_ KHEII 251_ HTGKK 256_ PYKCE 261_ ECGKA 266_ FNQSS 271_ TLTKH 276_ KKIHT 281_ GEKPY 286_ KCEEC 291_ GKAFN 296_ QSSTL 301_ TKHKK 306_ IHTGE 311_ KPYVC 316_ EECGK 321_ AFKYS 326_ RILTT 331_ HKRIH 336_ TGEKP 341_ YKCNK 346_ CGKAF 351_ IASST 356_ LSRHE 361_ FIHMG 366_ KKHYK 371_ CEECG 376_ KAFIW 381_ SSVLT 386_ RHKRV 391_ HTGEK 396_ PYKCE 401_ ECGKA 406_ FKYSS 411_ TLSSH 416_ KRSHT 421_ GEKPY 426_ KCEEC 431_ GKAFV 436_ ASSTL 441_ SKHEI 446_ IHTGK 451_ KPYKC 456_ EECGK 461_ AFNQS 466_ SSLTK 471_ HKKIH 476_ TGEKP 481_ YKCEE 486_ CGKAF 491_ NQSSS 496_ LTKHK 501_ KIHTG 506_ EKPYK 511_ CEECG 516_ KAFNQ 521_ SSTLI 526_ KHKKI 531_ HTREK 536_ PYKCE 541_ ECGKA 546_ FHLST 551_ HLTTH 556_ KILHT 561_ GEKPY 566_ RCREC 571_ GKAFN 576_ HSATL 581_ SSHKK 586_ IHSGE 591_ KPYEC 596_ DKCGK 601_ AFISP 606_ SSLSR 611_HEIIH
1: Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305)