Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)
1_MGAFL 6_ DKPKM 11_ EKHNA 16_ QGQGN 21_ GLRYG 26_ LSSMQ 31_ GWRVE 36_ MEDAH 41_ TAVIG 46_ LPSGL 51_ ESWSF 56_ FAVYD 61_ GHAGS 66_ QVAKY 71_ CCEHL 76_ LDHIT 81_ NNQDF 86_ KGSAG 91_ APSVE 96_ NVKNG 101_ IRTGF 106_ LEIDE 111_ HMRVM 116_ SEKKH 121_ GADRS 126_ GSTAV 131_ GVLIS 136_ PQHTY 141_ FINCG 146_ DSRGL 151_ LCRNR 156_ KVHFF 161_ TQDHK 166_ PSNPL 171_ EKERI 176_ QNAGG 181_ SVMIQ 186_ RVNGS 191_ LAVSR 196_ ALGDF 201_ DYKCV 206_ HGKGP 211_ TEQLV 216_ SPEPE 221_ VHDIE 226_ RSEED 231_ DQFII 236_ LACDG 241_ IWDVM 246_ GNEEL 251_ CDFVR 256_ SRLEV 261_ TDDLE 266_ KVCNE 271_ VVDTC 276_ LYKGS 281_ RDNMS 286_ VILIC 291_ FPNAP 296_ KVSPE 301_ AVKKE 306_ AELDK 311_ YLECR 316_ VEEII 321_ KKQGE 326_ GVPDL 331_ VHVMR 336_ TLASE 341_ NIPSL 346_ PPGGE 351_ LASKR 356_ NVIEA 361_ VYNRL 366_ NPYKN 371_ DDTDS 376_TSTDD
1: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB