Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
1_MQRGA 6_ ALCLR 11_ LWLCL 16_ GLLDG 21_ LVSGY 26_ SMTPP 31_ TLNIT 36_ EESHV 41_ IDTGD 46_ SLSIS 51_ CRGQH 56_ PLEWA 61_ WPGAQ 66_ EAPAT 71_ GDKDS 76_ EDTGV 81_ VRDCE 86_ GTDAR 91_ PYCKV 96_ LLLHE 101_ VHAND 106_ TGSYV 111_ CYYKY 116_ IKARI 121_ EGTTA 126_ ASSYV 131_ FVRDF 136_ EQPFI 141_ NKPDT 146_ LLVNR 151_ KDAMW 156_ VPCLV 161_ SIPGL 166_ NVTLR 171_ SQSSV 176_ LWPDG 181_ QEVVW 186_ DDRRG 191_ MLVST 196_ PLLHD 201_ ALYLQ 206_ CETTW 211_ GDQDF 216_ LSNPF 221_ LVHIT 226_ GNELY 231_ DIQLL 236_ PRKSL 241_ ELLVG 246_ EKLVL 251_ NCTVW 256_ AEFNS 261_ GVTFD 266_ WDYPG 271_ KQAER 276_ GKWVP 281_ ERRSQ 286_ QTHTE 291_ LSSIL 296_ TIHNV 301_ SQHDL 306_ GSYVC 311_ KANNG 316_ IQRFR 321_ ESTEV 326_ IVHEN 331_ PFISV 336_ EWLKG 341_ PILEA 346_ TAGDE 351_ LVKLP 356_ VKLAA 361_ YPPPE 366_ FQWYK 371_ DGKAL 376_ SGRHS 381_ PHALV 386_ LKEVT 391_ EASTG 396_ TYTLA 401_ LWNSA 406_ AGLRR 411_ NISLE 416_ LVVNV 421_ PPQIH 426_ EKEAS 431_ SPSIY 436_ SRHSR 441_ QALTC 446_ TAYGV 451_ PLPLS 456_ IQWHW 461_ RPWTP 466_ CKMFA 471_ QRSLR 476_ RRQQQ 481_ DLMPQ 486_ CRDWR 491_ AVTTQ 496_ DAVNP 501_ IESLD 506_ TWTEF 511_ VEGKN 516_ KTVSK 521_ LVIQN 526_ ANVSA 531_ MYKCV 536_ VSNKV 541_ GQDER 546_ LIYFY 551_ VTTIP 556_ DGFTI 561_ ESKPS 566_ EELLE 571_ GQPVL 576_ LSCQA 581_ DSYKY 586_ EHLRW 591_ YRLNL 596_ STLHD 601_ AHGNP 606_ LLLDC 611_ KNVHL 616_ FATPL 621_ AASLE 626_ EVAPG 631_ ARHAT 636_ LSLSI 641_ PRVAP 646_ EHEGH 651_ YVCEV 656_ QDRRS 661_ HDKHC 666_ HKKYL 671_ SVQAL 676_ EAPRL 681_ TQNLT 686_ DLLVN 691_ VSDSL 696_ EMQCL 701_ VAGAH 706_ APSIV 711_ WYKDE 716_ RLLEE 721_ KSGVD 726_ LADSN 731_ QKLSI 736_ QRVRE 741_ EDAGR 746_ YLCSV 751_ CNAKG 756_ CVNSS 761_ ASVAV 766_ EGSED 771_ KGSME 776_ IVILV 781_ GTGVI 786_ AVFFW 791_ VLLLL 796_ IFCNM 801_ RRPAH 806_ ADIKT 811_ GYLSI 816_ IMDPG 821_ EVPLE 826_ EQCEY 831_ LSYDA 836_ SQWEF 841_ PRERL 846_ HLGRV 851_ LGYGA 856_ FGKVV 861_ EASAF 866_ GIHKG 871_ SSCDT 876_ VAVKM 881_ LKEGA 886_ TASEH 891_ RALMS 896_ ELKIL 901_ IHIGN 906_ HLNVV 911_ NLLGA 916_ CTKPQ 921_ GPLMV 926_ IVEFC 931_ KYGNL 936_ SNFLR 941_ AKRDA 946_ FSPCA 951_ EKSPE 956_ QRGRF 961_ RAMVE 966_ LARLD 971_ RRRPG 976_ SSDRV 981_ LFARF 986_ SKTEG 991_ GARRA 996_ SPDQE 1001_ AEDLW 1006_ LSPLT 1011_ MEDLV 1016_ CYSFQ 1021_ VARGM 1026_ EFLAS 1031_ RKCIH 1036_ RDLAA 1041_ RNILL 1046_ SESDV 1051_ VKICD 1056_ FGLAR 1061_ DIYKD 1066_ PDYVR 1071_ KGSAR 1076_ LPLKW 1081_ MAPES 1086_ IFDKV 1091_ YTTQS 1096_ DVWSF 1101_ GVLLW 1106_ EIFSL 1111_ GASPY 1116_ PGVQI 1121_ NEEFC 1126_ QRLRD 1131_ GTRMR 1136_ APELA 1141_ TPAIR 1146_ RIMLN 1151_ CWSGD 1156_ PKARP 1161_ AFSEL 1166_ VEILG 1171_ DLLQG 1176_ RGLQE 1181_ EEEVC 1186_ MAPRS 1191_ SQSSE 1196_ EGSFS 1201_ QVSTM 1206_ ALHIA 1211_ QADAE 1216_ DSPPS 1221_ LQRHS 1226_ LAARY 1231_ YNWVS 1236_ FPGCL 1241_ ARGAE 1246_ TRGSS 1251_ RMKTF 1256_ EEFPM 1261_ TPTTY 1266_ KGSVD 1271_ NQTDS 1276_ GMVLA 1281_ SEEFE 1286_ QIESR 1291_ HRQES 1296_ GFSCK 1301_ GPGQN 1306_ VAVTR 1311_ AHPDS 1316_ QGRRR 1321_ RPERG 1326_ ARGGQ 1331_ VFYNS 1336_ EYGEL 1341_ SEPSE 1346_ EDHCS 1351_ PSARV 1356_TFFTD
1: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'