Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
1_MQSKV 6_ LLAVA 11_ LWLCV 16_ ETRAA 21_ SVGLP 26_ SVSLD 31_ LPRLS 36_ IQKDI 41_ LTIKA 46_ NTTLQ 51_ ITCRG 56_ QRDLD 61_ WLWPN 66_ NQSGS 71_ EQRVE 76_ VTECS 81_ DGLFC 86_ KTLTI 91_ PKVIG 96_ NDTGA 101_ YKCFY 106_ RETDL 111_ ASVIY 116_ VYVQD 121_ YRSPF 126_ IASVS 131_ DQHGV 136_ VYITE 141_ NKNKT 146_ VVIPC 151_ LGSIS 156_ NLNVS 161_ LCARY 166_ PEKRF 171_ VPDGN 176_ RISWD 181_ SKKGF 186_ TIPSY 191_ MISYA 196_ GMVFC 201_ EAKIN 206_ DESYQ 211_ SIMYI 216_ VVVVG 221_ YRIYD 226_ VVLSP 231_ SHGIE 236_ LSVGE 241_ KLVLN 246_ CTART 251_ ELNVG 256_ IDFNW 261_ EYPSS 266_ KHQHK 271_ KLVNR 276_ DLKTQ 281_ SGSEM 286_ KKFLS 291_ TLTID 296_ GVTRS 301_ DQGLY 306_ TCAAS 311_ SGLMT 316_ KKNST 321_ FVRVH 326_ EKPFV 331_ AFGSG 336_ MESLV 341_ EATVG 346_ ERVRI 351_ PAKYL 356_ GYPPP 361_ EIKWY 366_ KNGIP 371_ LESNH 376_ TIKAG 381_ HVLTI 386_ MEVSE 391_ RDTGN 396_ YTVIL 401_ TNPIS 406_ KEKQS 411_ HVVSL 416_ VVYVP 421_ PQIGE 426_ KSLIS 431_ PVDSY 436_ QYGTT 441_ QTLTC 446_ TVYAI 451_ PPPHH 456_ IHWYW 461_ QLEEE 466_ CANEP 471_ SQAVS 476_ VTNPY 481_ PCEEW 486_ RSVED 491_ FQGGN 496_ KIEVN 501_ KNQFA 506_ LIEGK 511_ NKTVS 516_ TLVIQ 521_ AANVS 526_ ALYKC 531_ EAVNK 536_ VGRGE 541_ RVISF 546_ HVTRG 551_ PEITL 556_ QPDMQ 561_ PTEQE 566_ SVSLW 571_ CTADR 576_ STFEN 581_ LTWYK 586_ LGPQP 591_ LPIHV 596_ GELPT 601_ PVCKN 606_ LDTLW 611_ KLNAT 616_ MFSNS 621_ TNDIL 626_ IMELK 631_ NASLQ 636_ DQGDY 641_ VCLAQ 646_ DRKTK 651_ KRHCV 656_ VRQLT 661_ VLERV 666_ APTIT 671_ GNLEN 676_ QTTSI 681_ GESIE 686_ VSCTA 691_ SGNPP 696_ PQIMW 701_ FKDNE 706_ TLVED 711_ SGIVL 716_ KDGNR 721_ NLTIR 726_ RVRKE 731_ DEGLY 736_ TCQAC 741_ SVLGC 746_ AKVEA 751_ FFIIE 756_ GAQEK 761_ TNLEI 766_ IILVG 771_ TAVIA 776_ MFFWL 781_ LLVII 786_ LRTVK 791_ RANGG 796_ ELKTG 801_ YLSIV 806_ MDPDE 811_ LPLDE 816_ HCERL 821_ PYDAS 826_ KWEFP 831_ RDRLK 836_ LGKPL 841_ GRGAF 846_ GQVIE 851_ ADAFG 856_ IDKTA 861_ TCRTV 866_ AVKML 871_ KEGAT 876_ HSEHR 881_ ALMSE 886_ LKILI 891_ HIGHH 896_ LNVVN 901_ LLGAC 906_ TKPGG 911_ PLMVI 916_ VEFCK 921_ FGNLS 926_ TYLRS 931_ KRNEF 936_ VPYKT 941_ KGARF 946_ RQGKD 951_ YVGAI 956_ PVDLK 961_ RRLDS 966_ ITSSQ 971_ SSASS 976_ GFVEE 981_ KSLSD 986_ VEEEE 991_ APEDL 996_ YKDFL 1001_ TLEHL 1006_ ICYSF 1011_ QVAKG 1016_ MEFLA 1021_ SRKCI 1026_ HRDLA 1031_ ARNIL 1036_ LSEKN 1041_ VVKIC 1046_ DFGLA 1051_ RDIYK 1056_ DPDYV 1061_ RKGDA 1066_ RLPLK 1071_ WMAPE 1076_ TIFDR 1081_ VYTIQ 1086_ SDVWS 1091_ FGVLL 1096_ WEIFS 1101_ LGASP 1106_ YPGVK 1111_ IDEEF 1116_ CRRLK 1121_ EGTRM 1126_ RAPDY 1131_ TTPEM 1136_ YQTML 1141_ DCWHG 1146_ EPSQR 1151_ PTFSE 1156_ LVEHL 1161_ GNLLQ 1166_ ANAQQ 1171_ DGKDY 1176_ IVLPI 1181_ SETLS 1186_ MEEDS 1191_ GLSLP 1196_ TSPVS 1201_ CMEEE 1206_ EVCDP 1211_ KFHYD 1216_ NTAGI 1221_ SQYLQ 1226_ NSKRK 1231_ SRPVS 1236_ VKTFE 1241_ DIPLE 1246_ EPEVK 1251_ VIPDD 1256_ NQTDS 1261_ GMVLA 1266_ SEELK 1271_ TLEDR 1276_ TKLSP 1281_ SFGGM 1286_ VPSKS 1291_ RESVA 1296_ SEGSN 1301_ QTSGY 1306_ QSGYH 1311_ SDDTD 1316_ TTVYS 1321_ SEEAE 1326_ LLKLI 1331_ EIGVQ 1336_ TGSTA 1341_ QILQP 1346_ DSGTT 1351_LSSPP
1: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC