26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)
1_MPDYL 6_ GADQR 11_ KTKED 16_ EKDDK 21_ PIRAL 26_ DEGDI 31_ ALLKT 36_ YGQST 41_ YSRQI 46_ KQVED 51_ DIQQL 56_ LKKIN 61_ ELTGI 66_ KESDT 71_ GLAPP 76_ ALWDL 81_ AADKQ 86_ TLQSE 91_ QPLQV 96_ ARCTK 101_ IINAD 106_ SEDPK 111_ YIINV 116_ KQFAK 121_ FVVDL 126_ SDQVA 131_ PTDIE 136_ EGMRV 141_ GVDRN 146_ KYQIH 151_ IPLPP 156_ KIDPT 161_ VTMMQ 166_ VEEKP 171_ DVTYS 176_ DVGGC 181_ KEQIE 186_ KLREV 191_ VETPL 196_ LHPER 201_ FVNLG 206_ IEPPK 211_ GVLLF 216_ GPPGT 221_ GKTLC 226_ ARAVA 231_ NRTDA 236_ CFIRV 241_ IGSEL 246_ VQKYV 251_ GEGAR 256_ MVREL 261_ FEMAR 266_ TKKAC 271_ LIFFD 276_ EIDAI 281_ GGARF 286_ DDGAG 291_ GDNEV 296_ QRTML 301_ ELINQ 306_ LDGFD 311_ PRGNI 316_ KVLMA 321_ TNRPD 326_ TLDPA 331_ LMRPG 336_ RLDRK 341_ IEFSL 346_ PDLEG 351_ RTHIF 356_ KIHAR 361_ SMSVE 366_ RDIRF 371_ ELLAR 376_ LCPNS 381_ TGAEI 386_ RSVCT 391_ EAGMF 396_ AIRAR 401_ RKIAT 406_ EKDFL 411_ EAVNK 416_ VIKSY 421_ AKFSA 426_TPRYM
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides