Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)
1_MGVKA 6_ SQTGF 11_ VVLVL 16_ LQCCS 21_ AYKLV 26_ CYYTS 31_ WSQYR 36_ EGDGS 41_ CFPDA 46_ LDRFL 51_ CTHII 56_ YSFAN 61_ ISNDH 66_ IDTWE 71_ WNDVT 76_ LYGML 81_ NTLKN 86_ RNPNL 91_ KTLLS 96_ VGGWN 101_ FGSQR 106_ FSKIA 111_ SNTQS 116_ RRTFI 121_ KSVPP 126_ FLRTH 131_ GFDGL 136_ DLAWL 141_ YPGRR 146_ DKQHF 151_ TTLIK 156_ EMKAE 161_ FIKEA 166_ QPGKK 171_ QLLLS 176_ AALSA 181_ GKVTI 186_ DSSYD 191_ IAKIS 196_ QHLDF 201_ ISIMT 206_ YDFHG 211_ AWRGT 216_ TGHHS 221_ PLFRG 226_ QEDAS 231_ PDRFS 236_ NTDYA 241_ VGYML 246_ RLGAP 251_ ASKLV 256_ MGIPT 261_ FGRSF 266_ TLASS 271_ ETGVG 276_ APISG 281_ PGIPG 286_ RFTKE 291_ AGTLA 296_ YYEIC 301_ DFLRG 306_ ATVHR 311_ ILGQQ 316_ VPYAT 321_ KGNQW 326_ VGYDD 331_ QESVK 336_ SKVQY 341_ LKDRQ 346_ LAGAM 351_ VWALD 356_ LDDFQ 361_ GSFCG 366_ QDLRF 371_ PLTNA 376_IKDAL
1: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung