Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1)
1_MPQLD 6_ SGGGG 11_ AGGGD 16_ DLGAP 21_ DELLA 26_ FQDEG 31_ EEQDD 36_ KSRDS 41_ AAGPE 46_ RDLAE 51_ LKSSL 56_ VNESE 61_ GAAGG 66_ AGIPG 71_ VPGAG 76_ AGARG 81_ EAEAL 86_ GREHA 91_ AQRLF 96_ PDKLP 101_ EPLED 106_ GLKAP 111_ ECTSG 116_ MYKET 121_ VYSAF 126_ NLLMH 131_ YPPPS 136_ GAGQH 141_ PQPQP 146_ PLHKA 151_ NQPPH 156_ GVPQL 161_ SLYEH 166_ FNSPH 171_ PTPAP 176_ ADISQ 181_ KQVHR 186_ PLQTP 191_ DLSGF 196_ YSLTS 201_ GSMGQ 206_ LPHTV 211_ SWFTH 216_ PSLML 221_ GSGVP 226_ GHPAA 231_ IPHPA 236_ IVPPS 241_ GKQEL 246_ QPFDR 251_ NLKTQ 256_ AESKA 261_ EKEAK 266_ KPTIK 271_ KPLNA 276_ FMLYM 281_ KEMRA 286_ KVIAE 291_ CTLKE 296_ SAAIN 301_ QILGR 306_ RWHAL 311_ SREEQ 316_ AKYYE 321_ LARKE 326_ RQLHM 331_ QLYPG 336_ WSARD 341_ NYGKK 346_ KRRSR 351_ EKHQE 356_ STTET 361_ NWPRE 366_ LKDGN 371_ GQESL 376_SMSSS
1: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes