ADP-ribosylation factor-like protein 2
1_MGLLT 6_ ILKKM 11_ KQKER 16_ ELRLL 21_ MLGLD 26_ NAGKT 31_ TILKK 36_ FNGED 41_ IDTIS 46_ PTLGF 51_ NIKTL 56_ EHRGF 61_ KLNIW 66_ DVGGQ 71_ KSLRS 76_ YWRNY 81_ FESTD 86_ GLIWV 91_ VDSAD 96_ RQRMQ 101_ DCQRE 106_ LQSLL 111_ VEERL 116_ AGATL 121_ LIFAN 126_ KQDLP 131_ GALSS 136_ NAIRE 141_ VLELD 146_ SIRSH 151_ HWCIQ 156_ GCSAV 161_ TGENL 166_ LPGID 171_ WLLDD 176_ISSRI
1: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (PubMed:10831612, PubMed:16525022, PubMed:18234692, PubMed:18588884, PubMed:20740604). Also regulates mitochondrial integrity and function (PubMed:30945270)