ADP-ribosylation factor-like protein 3
1_MGLLS 6_ ILRKL 11_ KSAPD 16_ QEVRI 21_ LLLGL 26_ DNAGK 31_ TTLLK 36_ QLASE 41_ DISHI 46_ TPTQG 51_ FNIKS 56_ VQSQG 61_ FKLNV 66_ WDIGG 71_ QRKIR 76_ PYWKN 81_ YFENT 86_ DILIY 91_ VIDSA 96_ DRKRF 101_ EETGQ 106_ ELAEL 111_ LEEEK 116_ LSCVP 121_ VLIFA 126_ NKQDL 131_ LTAAP 136_ ASEIA 141_ EGLNL 146_ HTIRD 151_ RVWQI 156_ QSCSA 161_ LTGEG 166_ VQDGM 171_ NWVCK 176_NVNAK
1: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity)