E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)
1_MATLV 6_ VNKLG 11_ AGVDS 16_ GRQGS 21_ RGTAV 26_ VKVLE 31_ CGVCE 36_ DVFSL 41_ QGDKV 46_ PRLLL 51_ CGHTV 56_ CHDCL 61_ TRLPL 66_ HGRAI 71_ RCPFD 76_ RQVTD 81_ LGDSG 86_ VWGLK 91_ KNFAL 96_ LELLE 101_ RLQNG 106_ PIGQY 111_ GAAEE 116_ SIGIS 121_ GESII 126_ RCDED 131_ EAHLA 136_ SVYCT 141_ VCATH 146_ LCSEC 151_ SQVTH 156_ STKTL 161_ AKHRR 166_ VPLAD 171_ KPHEK 176_ TMCSQ 181_ HQVHA 186_ IEFVC 191_ LEEGC 196_ QTSPL 201_ MCCVC 206_ KEYGK 211_ HQGHK 216_ HSVLE 221_ PEANQ 226_ IRASI 231_ LDMAH 236_ CIRTF 241_ TEEIS 246_ DYSRK 251_ LVGIV 256_ QHIEG 261_ GEQIV 266_ EDGIG 271_ MAHTE 276_ HVPGT 281_ AENAR 286_ SCIRA 291_ YFYDL 296_ HETLC 301_ RQEEM 306_ ALSVV 311_ DAHVR 316_ EKLIW 321_ LRQQQ 326_ EDMTI 331_ LLSEV 336_ SAACL 341_ HCEKT 346_ LQQDD 351_ CRVVL 356_ AKQEI 361_ TRLLE 366_ TLQKQ 371_ QQQFT 376_ EVADH 381_ IQLDA 386_ SIPVT 391_ FTKDN 396_ RVHIG 401_ PKMEI 406_ RVVTL 411_ GLDGA 416_ GKTTI 421_ LFKLK 426_ QDEFM 431_ QPIPT 436_ IGFNV 441_ ETVEY 446_ KNLKF 451_ TIWDV 456_ GGKHK 461_ LRPLW 466_ KHYYL 471_ NTQAV 476_ VFVVD 481_ SSHRD 486_ RISEA 491_ HSELA 496_ KLLTE 501_ KELRD 506_ ALLLI 511_ FANKQ 516_ DVAGA 521_ LSVEE 526_ ITELL 531_ SLHKL 536_ CCGRS 541_ WYIQG 546_ CDARS 551_ GMGLY 556_ EGLDW 561_ LSRQL 566_VAAGV
1: Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090)
2: (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection