Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
1_MLARR 6_ KPVLP 11_ ALTIN 16_ PTIAE 21_ GPSPT 26_ SEGAS 31_ EANLV 36_ DLQKK 41_ LEELE 46_ LDEQQ 51_ KKRLE 56_ AFLTQ 61_ KAKVG 66_ ELKDD 71_ DFERI 76_ SELGA 81_ GNGGV 86_ VTKVQ 91_ HRPSG 96_ LIMAR 101_ KLIHL 106_ EIKPA 111_ IRNQI 116_ IRELQ 121_ VLHEC 126_ NSPYI 131_ VGFYG 136_ AFYSD 141_ GEISI 146_ CMEHM 151_ DGGSL 156_ DQVLK 161_ EAKRI 166_ PEEIL 171_ GKVSI 176_ AVLRG 181_ LAYLR 186_ EKHQI 191_ MHRDV 196_ KPSNI 201_ LVNSR 206_ GEIKL 211_ CDFGV 216_ SGQLI 221_ DSMAN 226_ SFVGT 231_ RSYMA 236_ PERLQ 241_ GTHYS 246_ VQSDI 251_ WSMGL 256_ SLVEL 261_ AVGRY 266_ PIPPP 271_ DAKEL 276_ EAIFG 281_ RPVVD 286_ GEEGE 291_ PHSIS 296_ PRPRP 301_ PGRPV 306_ SGHGM 311_ DSRPA 316_ MAIFE 321_ LLDYI 326_ VNEPP 331_ PKLPN 336_ GVFTP 341_ DFQEF 346_ VNKCL 351_ IKNPA 356_ ERADL 361_ KMLTN 366_ HTFIK 371_ RSEVE 376_ EVDFA 381_ GWLCK 386_ TLRLN 391_QPGTP
1: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126)