Neuronal acetylcholine receptor subunit alpha-7
1_MRCSP 6_ GGVWL 11_ ALAAS 16_ LLHVS 21_ LQGEF 26_ QRKLY 31_ KELVK 36_ NYNPL 41_ ERPVA 46_ NDSQP 51_ LTVYF 56_ SLSLL 61_ QIMDV 66_ DEKNQ 71_ VLTTN 76_ IWLQM 81_ SWTDH 86_ YLQWN 91_ VSEYP 96_ GVKTV 101_ RFPDG 106_ QIWKP 111_ DILLY 116_ NSADE 121_ RFDAT 126_ FHTNV 131_ LVNSS 136_ GHCQY 141_ LPPGI 146_ FKSSC 151_ YIDVR 156_ WFPFD 161_ VQHCK 166_ LKFGS 171_ WSYGG 176_ WSLDL 181_ QMQEA 186_ DISGY 191_ IPNGE 196_ WDLVG 201_ IPGKR 206_ SERFY 211_ ECCKE 216_ PYPDV 221_ TFTVT 226_ MRRRT 231_ LYYGL 236_ NLLIP 241_ CVLIS 246_ ALALL 251_ VFLLP 256_ ADSGE 261_ KISLG 266_ ITVLL 271_ SLTVF 276_ MLLVA 281_ EIMPA 286_ TSDSV 291_ PLIAQ 296_ YFAST 301_ MIIVG 306_ LSVVV 311_ TVIVL 316_ QYHHH 321_ DPDGG 326_ KMPKW 331_ TRVIL 336_ LNWCA 341_ WFLRM 346_ KRPGE 351_ DKVRP 356_ ACQHK 361_ QRRCS 366_ LASVE 371_ MSAVA 376_ PPPAS 381_ NGNLL 386_ YIGFR 391_ GLDGV 396_ HCVPT 401_ PDSGV 406_ VCGRM 411_ ACSPT 416_ HDEHL 421_ LHGGQ 426_ PPEGD 431_ PDLAK 436_ ILEEV 441_ RYIAN 446_ RFRCQ 451_ DESEA 456_ VCSEW 461_ KFAAC 466_ VVDRL 471_ CLMAF 476_ SVFTI 481_ ICTIG 486_ ILMSA 491_ PNFVE 496_AVSKD
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:15609996, PubMed:33735609, PubMed:8145738). CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability (PubMed:31560909, PubMed:33735609, PubMed:38382524, PubMed:8145738). Also forms heteropentamers with CHRNB2, mainly expressed in basal forebrain cholinergic neurons. Involved in the modulation of calcium-dependent signaling pathways and influences the release of neurotransmitters, including dopamine, glutamate and GABA (PubMed:33239400). Also expressed in non-neuronal cells such as immune cells like lymphocytes, monocytes and macrophages (PubMed:12508119, PubMed:16968406, PubMed:25259522). In T cells, activation induces metabotropic signaling that results in an increase of intracellular Ca2+ concentrations, independent of ionotropic receptor functions (PubMed:17709503). In macrophages, required for acetylcholine-mediated inhibition of TNF and other inflammatory cytokine release (PubMed:12508119). Once activated by acetylcholine, nicotine or other agonists, selectively inhibits production of pro-inflammatory cytokines while leaving anti-inflammatory cytokines undisturbed (PubMed:12508119, PubMed:25259522). Stimulates the cholinergic anti-inflammatory pathway, controlling inflammation by inhibiting NFKB nuclear translocation and activating the JAK2-STAT3 pathway, independently of ion channel activity (PubMed:16968406, PubMed:25259522). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through internal stores and decreasing basal ATP release (By similarity)