Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
1_MADLD 6_ KLNID 11_ SIIQR 16_ LLEVR 21_ GSKPG 26_ KNVQL 31_ QENEI 36_ RGLCL 41_ KSREI 46_ FLSQP 51_ ILLEL 56_ EAPLK 61_ ICGDI 66_ HGQYY 71_ DLLRL 76_ FEYGG 81_ FPPES 86_ NYLFL 91_ GDYVD 96_ RGKQS 101_ LETIC 106_ LLLAY 111_ KIKYP 116_ ENFFL 121_ LRGNH 126_ ECASI 131_ NRIYG 136_ FYDEC 141_ KRRYN 146_ IKLWK 151_ TFTDC 156_ FNCLP 161_ IAAIV 166_ DEKIF 171_ CCHGG 176_ LSPDL 181_ QSMEQ 186_ IRRIM 191_ RPTDV 196_ PDQGL 201_ LCDLL 206_ WSDPD 211_ KDVLG 216_ WGEND 221_ RGVSF 226_ TFGAE 231_ VVAKF 236_ LHKHD 241_ LDLIC 246_ RAHQV 251_ VEDGY 256_ EFFAK 261_ RQLVT 266_ LFSAP 271_ NYCGE 276_ FDNAG 281_ AMMSV 286_ DETLM 291_ CSFQI 296_ LKPAE 301_ KKKPN 306_ ATRPV 311_ TPPRG 316_MITKQ
1: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509)