Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
1_MPALA 6_ RDGGQ 11_ LPLLV 16_ VFSAM 21_ IFGTI 26_ TNQDL 31_ PVIKC 36_ VLINH 41_ KNNDS 46_ SVGKS 51_ SSYPM 56_ VSESP 61_ EDLGC 66_ ALRPQ 71_ SSGTV 76_ YEAAA 81_ VEVDV 86_ SASIT 91_ LQVLV 96_ DAPGN 101_ ISCLW 106_ VFKHS 111_ SLNCQ 116_ PHFDL 121_ QNRGV 126_ VSMVI 131_ LKMTE 136_ TQAGE 141_ YLLFI 146_ QSEAT 151_ NYTIL 156_ FTVSI 161_ RNTLL 166_ YTLRR 171_ PYFRK 176_ MENQD 181_ ALVCI 186_ SESVP 191_ EPIVE 196_ WVLCD 201_ SQGES 206_ CKEES 211_ PAVVK 216_ KEEKV 221_ LHELF 226_ GTDIR 231_ CCARN 236_ ELGRE 241_ CTRLF 246_ TIDLN 251_ QTPQT 256_ TLPQL 261_ FLKVG 266_ EPLWI 271_ RCKAV 276_ HVNHG 281_ FGLTW 286_ ELENK 291_ ALEEG 296_ NYFEM 301_ STYST 306_ NRTMI 311_ RILFA 316_ FVSSV 321_ ARNDT 326_ GYYTC 331_ SSSKH 336_ PSQSA 341_ LVTIV 346_ EKGFI 351_ NATNS 356_ SEDYE 361_ IDQYE 366_ EFCFS 371_ VRFKA 376_ YPQIR 381_ CTWTF 386_ SRKSF 391_ PCEQK 396_ GLDNG 401_ YSISK 406_ FCNHK 411_ HQPGE 416_ YIFHA 421_ ENDDA 426_ QFTKM 431_ FTLNI 436_ RRKPQ 441_ VLAEA 446_ SASQA 451_ SCFSD 456_ GYPLP 461_ SWTWK 466_ KCSDK 471_ SPNCT 476_ EEITE 481_ GVWNR 486_ KANRK 491_ VFGQW 496_ VSSST 501_ LNMSE 506_ AIKGF 511_ LVKCC 516_ AYNSL 521_ GTSCE 526_ TILLN 531_ SPGPF 536_ PFIQD 541_ NISFY 546_ ATIGV 551_ CLLFI 556_ VVLTL 561_ LICHK 566_ YKKQF 571_ RYESQ 576_ LQMVQ 581_ VTGSS 586_ DNEYF 591_ YVDFR 596_ EYEYD 601_ LKWEF 606_ PRENL 611_ EFGKV 616_ LGSGA 621_ FGKVM 626_ NATAY 631_ GISKT 636_ GVSIQ 641_ VAVKM 646_ LKEKA 651_ DSSER 656_ EALMS 661_ ELKMM 666_ TQLGS 671_ HENIV 676_ NLLGA 681_ CTLSG 686_ PIYLI 691_ FEYCC 696_ YGDLL 701_ NYLRS 706_ KREKF 711_ HRTWT 716_ EIFKE 721_ HNFSF 726_ YPTFQ 731_ SHPNS 736_ SMPGS 741_ REVQI 746_ HPDSD 751_ QISGL 756_ HGNSF 761_ HSEDE 766_ IEYEN 771_ QKRLE 776_ EEEDL 781_ NVLTF 786_ EDLLC 791_ FAYQV 796_ AKGME 801_ FLEFK 806_ SCVHR 811_ DLAAR 816_ NVLVT 821_ HGKVV 826_ KICDF 831_ GLARD 836_ IMSDS 841_ NYVVR 846_ GNARL 851_ PVKWM 856_ APESL 861_ FEGIY 866_ TIKSD 871_ VWSYG 876_ ILLWE 881_ IFSLG 886_ VNPYP 891_ GIPVD 896_ ANFYK 901_ LIQNG 906_ FKMDQ 911_ PFYAT 916_ EEIYI 921_ IMQSC 926_ WAFDS 931_ RKRPS 936_ FPNLT 941_ SFLGC 946_ QLADA 951_ EEAMY 956_ QNVDG 961_ RVSEC 966_ PHTYQ 971_ NRRPF 976_ SREMD 981_ LGLLS 986_PQAQV
1: Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways