Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
1_MPQLY 6_ IYIRL 11_ LGAYL 16_ FIISR 21_ VQGQN 26_ LDSML 31_ HGTGM 36_ KSDSD 41_ QKKSE 46_ NGVTL 51_ APEDT 56_ LPFLK 61_ CYCSG 66_ HCPDD 71_ AINNT 76_ CITNG 81_ HCFAI 86_ IEEDD 91_ QGETT 96_ LASGC 101_ MKYEG 106_ SDFQC 111_ KDSPK 116_ AQLRR 121_ TIECC 126_ RTNLC 131_ NQYLQ 136_ PTLPP 141_ VVIGP 146_ FFDGS 151_ IRWLV 156_ LLISM 161_ AVCII 166_ AMIIF 171_ SSCFC 176_ YKHYC 181_ KSISS 186_ RRRYN 191_ RDLEQ 196_ DEAFI 201_ PVGES 206_ LKDLI 211_ DQSQS 216_ SGSGS 221_ GLPLL 226_ VQRTI 231_ AKQIQ 236_ MVRQV 241_ GKGRY 246_ GEVWM 251_ GKWRG 256_ EKVAV 261_ KVFFT 266_ TEEAS 271_ WFRET 276_ EIYQT 281_ VLMRH 286_ ENILG 291_ FIAAD 296_ IKGTG 301_ SWTQL 306_ YLITD 311_ YHENG 316_ SLYDF 321_ LKCAT 326_ LDTRA 331_ LLKLA 336_ YSAAC 341_ GLCHL 346_ HTEIY 351_ GTQGK 356_ PAIAH 361_ RDLKS 366_ KNILI 371_ KKNGS 376_ CCIAD 381_ LGLAV 386_ KFNSD 391_ TNEVD 396_ VPLNT 401_ RVGTK 406_ RYMAP 411_ EVLDE 416_ SLNKN 421_ HFQPY 426_ IMADI 431_ YSFGL 436_ IIWEM 441_ ARRCI 446_ TGGIV 451_ EEYQL 456_ PYYNM 461_ VPSDP 466_ SYEDM 471_ REVVC 476_ VKRLR 481_ PIVSN 486_ RWNSD 491_ ECLRA 496_ VLKLM 501_ SECWA 506_ HNPAS 511_ RLTAL 516_ RIKKT 521_ LAKMV 526_ESQDV
1: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity)