Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]
1_MDEPP 6_ FSEAA 11_ LEQAL 16_ GEPCD 21_ LDAAL 26_ LTDIE 31_ DMLQL 36_ INNQD 41_ SDFPG 46_ LFDPP 51_ YAGSG 56_ AGGTD 61_ PASPD 66_ TSSPG 71_ SLSPP 76_ PATLS 81_ SSLEA 86_ FLSGP 91_ QAAPS 96_ PLSPP 101_ QPAPT 106_ PLKMY 111_ PSMPA 116_ FSPGP 121_ GIKEE 126_ SVPLS 131_ ILQTP 136_ TPQPL 141_ PGALL 146_ PQSFP 151_ APAPP 156_ QFSST 161_ PVLGY 166_ PSPPG 171_ GFSTG 176_ SPPGN 181_ TQQPL 186_ PGLPL 191_ ASPPG 196_ VPPVS 201_ LHTQV 206_ QSVVP 211_ QQLLT 216_ VTAAP 221_ TAAPV 226_ TTTVT 231_ SQIQQ 236_ VPVLL 241_ QPHFI 246_ KADSL 251_ LLTAM 256_ KTDGA 261_ TVKAA 266_ GLSPL 271_ VSGTT 276_ VQTGP 281_ LPTLV 286_ SGGTI 291_ LATVP 296_ LVVDA 301_ EKLPI 306_ NRLAA 311_ GSKAP 316_ ASAQS 321_ RGEKR 326_ TAHNA 331_ IEKRY 336_ RSSIN 341_ DKIIE 346_ LKDLV 351_ VGTEA 356_ KLNKS 361_ AVLRK 366_ AIDYI 371_ RFLQH 376_ SNQKL 381_ KQENL 386_ SLRTA 391_ VHKSK 396_ SLKDL 401_ VSACG 406_ SGGNT 411_ DVLME 416_ GVKTE 421_ VEDTL 426_ TPPPS 431_ DAGSP 436_ FQSSP 441_ LSLGS 446_ RGSGS 451_ GGSGS 456_ DSEPD 461_ SPVFE 466_ DSKAK 471_ PEQRP 476_ SLHSR 481_ GMLDR 486_ SRLAL 491_ CTLVF 496_ LCLSC 501_ NPLAS 506_ LLGAR 511_ GLPSP 516_ SDTTS 521_ VYHSP 526_ GRNVL 531_ GTESR 536_ DGPGW 541_ AQWLL 546_ PPVVW 551_ LLNGL 556_ LVLVS 561_ LVLLF 566_ VYGEP 571_ VTRPH 576_ SGPAV 581_ YFWRH 586_ RKQAD 591_ LDLAR 596_ GDFAQ 601_ AAQQL 606_ WLALR 611_ ALGRP 616_ LPTSH 621_ LDLAC 626_ SLLWN 631_ LIRHL 636_ LQRLW 641_ VGRWL 646_ AGRAG 651_ GLQQD 656_ CALRV 661_ DASAS 666_ ARDAA 671_ LVYHK 676_ LHQLH 681_ TMGKH 686_ TGGHL 691_ TATNL 696_ ALSAL 701_ NLAEC 706_ AGDAV 711_ SVATL 716_ AEIYV 721_ AAALR 726_ VKTSL 731_ PRALH 736_ FLTRF 741_ FLSSA 746_ RQACL 751_ AQSGS 756_ VPPAM 761_ QWLCH 766_ PVGHR 771_ FFVDG 776_ DWSVL 781_ STPWE 786_ SLYSL 791_ AGNPV 796_ DPLAQ 801_ VTQLF 806_ REHLL 811_ ERALN 816_ CVTQP 821_ NPSPG 826_ SADGD 831_ KEFSD 836_ ALGYL 841_ QLLNS 846_ CSDAA 851_ GAPAY 856_ SFSIS 861_ SSMAT 866_ TTGVD 871_ PVAKW 876_ WASLT 881_ AVVIH 886_ WLRRD 891_ EEAAE 896_ RLCPL 901_ VEHLP 906_ RVLQE 911_ SERPL 916_ PRAAL 921_ HSFKA 926_ ARALL 931_ GCAKA 936_ ESGPA 941_ SLTIC 946_ EKASG 951_ YLQDS 956_ LATTP 961_ ASSSI 966_ DKAVQ 971_ LFLCD 976_ LLLVV 981_ RTSLW 986_ RQQQP 991_ PAPAP 996_ AAQGT 1001_ SSRPQ 1006_ ASALE 1011_ LRGFQ 1016_ RDLSS 1021_ LRRLA 1026_ QSFRP 1031_ AMRRV 1036_ FLHEA 1041_ TARLM 1046_ AGASP 1051_ TRTHQ 1056_ LLDRS 1061_ LRRRA 1066_ GPGGK 1071_ GGAVA 1076_ ELEPR 1081_ PTRRE 1086_ HAEAL 1091_ LLASC 1096_ YLPPG 1101_ FLSAP 1106_ GQRVG 1111_ MLAEA 1116_ ARTLE 1121_ KLGDR 1126_ RLLHD 1131_ CQQML 1136_ MRLGG 1141_GTTVT
1: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity)
2: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897)
3: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity)
4: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity)
5: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters
6: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters