Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)
1_MLSRS 6_ RCVSR 11_ AFSRS 16_ LSAFQ 21_ KGNCP 26_ LGRRS 31_ LPGVS 36_ LCQGP 41_ GYPNS 46_ RKVVI 51_ NNSVF 56_ SVRFF 61_ RTTAV 66_ CKDDL 71_ VTVKT 76_ PAFAE 81_ SVTEG 86_ DVRWE 91_ KAVGD 96_ TVAED 101_ EVVCE 106_ IETDK 111_ TSVQV 116_ PSPAN 121_ GVIEA 126_ LLVPD 131_ GGKVE 136_ GGTPL 141_ FTLRK 146_ TGAAP 151_ AKAKP 156_ AEAPA 161_ AAAPK 166_ AEPTA 171_ AAVPP 176_ PAAPI 181_ PTQMP 186_ PVPSP 191_ SQPPS 196_ GKPVS 201_ AVKPT 206_ VAPPL 211_ AEPGA 216_ GKGLR 221_ SEHRE 226_ KMNRM 231_ RQRIA 236_ QRLKE 241_ AQNTC 246_ AMLTT 251_ FNEID 256_ MSNIQ 261_ EMRAR 266_ HKEAF 271_ LKKHN 276_ LKLGF 281_ MSAFV 286_ KASAF 291_ ALQEQ 296_ PVVNA 301_ VIDDT 306_ TKEVV 311_ YRDYI 316_ DISVA 321_ VATPR 326_ GLVVP 331_ VIRNV 336_ EAMNF 341_ ADIER 346_ TITEL 351_ GEKAR 356_ KNELA 361_ IEDMD 366_ GGTFT 371_ ISNGG 376_ VFGSL 381_ FGTPI 386_ INPPQ 391_ SAILG 396_ MHGIF 401_ DRPVA 406_ IGGKV 411_ EVRPM 416_ MYVAL 421_ TYDHR 426_ LIDGR 431_ EAVTF 436_ LRKIK 441_ AAVED 446_PRVLL
1: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711, PubMed:30929736). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711)