Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)
1_MSLGR 6_ LCRLL 11_ KPALL 16_ CGALA 21_ APGLA 26_ GTMCA 31_ SRDDW 36_ RCARS 41_ MHEFS 46_ AKDID 51_ GHMVN 56_ LDKYR 61_ GFVCI 66_ VTNVA 71_ SQUGK 76_ TEVNY 81_ TQLVD 86_ LHARY 91_ AECGL 96_ RILAF 101_ PCNQF 106_ GKQEP 111_ GSNEE 116_ IKEFA 121_ AGYNV 126_ KFDMF 131_ SKICV 136_ NGDDA 141_ HPLWK 146_ WMKIQ 151_ PKGKG 156_ ILGNA 161_ IKWNF 166_ TKFLI 171_ DKNGC 176_ VVKRY 181_ GPMEE 186_ PLVIE 191_KDLPH
1: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Can reduce fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). Can also reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide (PubMed:17630701, PubMed:36608588)