Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
1_MTLGS 6_ PRKGL 11_ LMLLM 16_ ALVTQ 21_ GDPVK 26_ PSRGP 31_ LVTCT 36_ CESPH 41_ CKGPT 46_ CRGAW 51_ CTVVL 56_ VREEG 61_ RHPQE 66_ HRGCG 71_ NLHRE 76_ LCRGR 81_ PTEFV 86_ NHYCC 91_ DSHLC 96_ NHNVS 101_ LVLEA 106_ TQPPS 111_ EQPGT 116_ DGQLA 121_ LILGP 126_ VLALL 131_ ALVAL 136_ GVLGL 141_ WHVRR 146_ RQEKQ 151_ RGLHS 156_ ELGES 161_ SLILK 166_ ASEQG 171_ DSMLG 176_ DLLDS 181_ DCTTG 186_ SGSGL 191_ PFLVQ 196_ RTVAR 201_ QVALV 206_ ECVGK 211_ GRYGE 216_ VWRGL 221_ WHGES 226_ VAVKI 231_ FSSRD 236_ EQSWF 241_ RETEI 246_ YNTVL 251_ LRHDN 256_ ILGFI 261_ ASDMT 266_ SRNSS 271_ TQLWL 276_ ITHYH 281_ EHGSL 286_ YDFLQ 291_ RQTLE 296_ PHLAL 301_ RLAVS 306_ AACGL 311_ AHLHV 316_ EIFGT 321_ QGKPA 326_ IAHRD 331_ FKSRN 336_ VLVKS 341_ NLQCC 346_ IADLG 351_ LAVMH 356_ SQGSD 361_ YLDIG 366_ NNPRV 371_ GTKRY 376_ MAPEV 381_ LDEQI 386_ RTDCF 391_ ESYKW 396_ TDIWA 401_ FGLVL 406_ WEIAR 411_ RTIVN 416_ GIVED 421_ YRPPF 426_ YDVVP 431_ NDPSF 436_ EDMKK 441_ VVCVD 446_ QQTPT 451_ IPNRL 456_ AADPV 461_ LSGLA 466_ QMMRE 471_ CWYPN 476_ PSARL 481_ TALRI 486_ KKTLQ 491_ KISNS 496_PEKPK
1: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well